Abstract | AIM: METHODS: RESULTS: Compared with the reference values of blood glucose fluctuation parameters in China, gout patients had greater glycemic fluctuations including higher mean amplitude of glucose excursions (MAGE) (4.65 vs 1.94 mmol/L, P < .001), higher largest amplitude of blood glucose excursions (LAGE) (4.99 vs 3.72 mmol/L, P < .001) and higher standard deviations of blood glucose (SDBG) (1.36 vs 0.79 mmol/L, P < .001). MAGE was significantly correlated with uric acid (β = .007, P = .024) and HOMA- insulin resistance (IR) (β = .508, P = .03). Allopurinol treatment significantly reduced MAGE (4.16 vs 4.65 mmol/L, P < .001), SDBG (0.99 vs 1.36 mmol/L, P < .001) and HOMA-IR (2.26 vs 3.01, P < .001) in gout patients. CONCLUSION:
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Authors | Zepeng Mu, Jing Wang, Wei Wang, Wenshan Lv, Ying Chen, Fang Wang, Yuhang Zhao, Bingzi Dong, Yangang Wang, Zhongchao Wang |
Journal | International journal of rheumatic diseases
(Int J Rheum Dis)
Vol. 23
Issue 9
Pg. 1145-1151
(Aug 2020)
ISSN: 1756-185X [Electronic] England |
PMID | 32483927
(Publication Type: Journal Article)
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Copyright | © 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Biomarkers
- Blood Glucose
- Gout Suppressants
- Uric Acid
- Allopurinol
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Topics |
- Adult
- Aged
- Allopurinol
(adverse effects, therapeutic use)
- Biomarkers
(blood)
- Blood Glucose
(drug effects, metabolism)
- Blood Glucose Self-Monitoring
- Down-Regulation
- Female
- Gout
(blood, diagnosis, drug therapy)
- Gout Suppressants
(adverse effects, therapeutic use)
- Humans
- Hyperuricemia
(blood, diagnosis, drug therapy)
- Insulin Resistance
- Male
- Middle Aged
- Predictive Value of Tests
- Time Factors
- Treatment Outcome
- Uric Acid
(blood)
- Young Adult
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