Treatment of refractory cancer-associated hypercalcemia with aminohydroxypropylidene diphosphonate.

Abstract

The case history is presented of a 45-year-old woman who was receiving chemotherapy for a pulmonary adenocarcinoma and who developed severe symptomatic hypercalcemia. Despite intensive treatment with fluids, loop diuretics, prednisone, calcitonin and repeated doses of mithramycin, she remained hypercalcemic. She was then treated with aminohydroxypropylidene diphosphonate (APD) with consequent rapid normalization of the serum calcium and disappearance of symptoms. We conclude that APD is a valuable supplement to the treatment of malignant hypercalcemia in that it may be effective when traditional therapies have failed.

• Authors: J G Heaf, M Hansen
• Journal: Acta medica Scandinavica (Acta Med Scand) Vol. 224 Issue 3 Pg. 287-8 ( 1988) ISSN: 0001-6101 [Print] Sweden
• PMID: 3239457 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Diphosphonates
• Nitrosourea Compounds
• Taurine
• 1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea
• Pamidronate

Topics

• Adenocarcinoma (drug therapy)
• Antineoplastic Agents (adverse effects)
• Diphosphonates (therapeutic use)
• Female
• Humans
• Hypercalcemia (chemically induced, drug therapy)
• Lung Neoplasms (drug therapy)
• Middle Aged
• Nitrosourea Compounds (adverse effects)
• Pamidronate
• Taurine (adverse effects, analogs & derivatives)