Acne vulgaris is a chronic inflammatory
skin disease that mostly develops during adolescence and continues throughout adulthood. It affects the face, the main location of cosmetic appearance. Despite many developments in
acne treatment, various combination
therapies are needed to create the best option. Ninety patients were included in this study. We used the global
acne grading system (GAGS) and the lesion counting and photographic standards that were used by Hayashi et al., to assess
acne severity. The patients were randomly divided into three groups as group 1 (using only 5% BPO, twice a day), group 2 (using only the combination of 5% BPO + 3%
erythromycin, twice a day), and group 3 (using only the combination of 4% niacinamide + 1% gallic acid + 1%
lauric acid, twice a day). Thirty patients were included in each group. The scores were evaluated at weeks 0, 2, 4 and 8, and compared with each other. As a result of the study, all three treatment types were found to be effective. The combination of 4% niacinamide + 1% gallic acid + 1%
lauric acid can be used as an alternative topical treatment for
acne vulgaris to prevent resistance against topical
antibiotics and the side effects of some other treatments.