Benzoyl Peroxide

A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.

Also Known As:

Networked: 529 relevant articles (85 outcomes, 112 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Feldman, Steven R: 12 articles (06/2014 - 01/2005)
2.	Del Rosso, James Q: 10 articles (10/2014 - 06/2007)
3.	Tanghetti, Emil: 9 articles (12/2015 - 03/2006)
4.	Leyden, James J: 7 articles (06/2014 - 06/2002)
5.	Thiboutot, Diane: 7 articles (06/2013 - 05/2002)
6.	Gold, Michael H: 6 articles (12/2015 - 05/2006)
7.	Draelos, Zoe Diana: 6 articles (12/2015 - 02/2002)
8.	Eichenfield, Lawrence F: 6 articles (01/2015 - 11/2009)
9.	Sultana, Sarwat: 6 articles (01/2005 - 01/2003)
10.	Sharma, Sonia: 6 articles (01/2005 - 01/2003)

Related Diseases

1.	Acne Vulgaris 07/01/1979 - "The results of an open clinical trial of 200 patients in Singapore show that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without concomitant systemic therapy. " 07/01/2009 - "Benzoyl peroxide has a proven track record of safety and efficacy for the treatment of acne. " 07/01/2000 - "Despite many functions beneficial in acne therapy, benzoyl peroxide does not possess sebosuppressive capabilities. " 12/01/2015 - "Over-the-counter acne treatments have assumed more importance for the dermatologist as access and affordability of prescription acne medications has decreased.<br /> This research evaluated the efficacy of a three step acne treatment regimen containing stabilized botanical anti-inflammatory ingredients as compared to a currently marketed acne regimen.<br /> 80 female/male subjects 12+ years with mild to moderate acne (at least 10 inflammatory and 10 non-inflammatory lesions) were enrolled for 12 weeks and randomized to use the study botanical anti-inflammatory acne regimen or the traditional benzoyl peroxide comparator. " 01/01/1980 - "The results of our study have shown that this new, higher concentration formulation of benzoyl peroxide is effective in reducing the lesions of acne and is relatively nonirritating."
2.	Neoplasms (Cancer) 06/01/1986 - "The ability of benzoyl peroxide to enhance the progression of benign tumors to cancer should be considered when determining the human risk from exposure to this widely used chemical agent; in addition, biological assays specifically testing malignant progression may be essential and beneficial for determining an agent's carcinogenic risk." 01/14/2005 - "Stocks, an indigenous plant, in the modulation of benzoyl peroxide (BPO) treated and ultraviolet (UV) light irradiated tumor promotional events. " 01/14/2005 - "Balsamodendron mukul suppresses benzoyl peroxide and ultraviolet light induced tumor promotional events in Swiss mice." 12/15/2004 - "Benzoyl peroxide (BP), a tumor promoter, has been shown to cause free-radical-induced lipid peroxidation and membrane damage at toxic concentrations. " 10/01/2004 - "Treatment of dorsal shaven cutaneous portions of the mice with single topical application of benzoyl peroxide (BPO) followed by exposure to ultraviolet B (UVB) radiation induced significant oxidative stress and elevated the marker parameters of tumor promotion. "
3.	Rosacea (Acne Rosacea) 06/01/2014 - "Randomized, phase 2, dose-ranging study in the treatment of rosacea with encapsulated benzoyl peroxide gel." 05/01/2004 - "Overall rosacea severity, Physician Global Assessment, and Patient's Global Assessment at the end of treatment were all significantly improved with benzoyl peroxide/clindamycin compared with vehicle (P = 0.0101, 0.0026, and 0.0002, respectively). " 06/01/2014 - "Compare the safety and efficacy of 1% and 5% silica encapsulated benzoyl peroxide (E-BPO) in patients with papulopustular rosacea. " 06/01/2004 - "Photographic review of results from a clinical study comparing benzoyl peroxide 5%/clindamycin 1% topical gel with vehicle in the treatment of rosacea." 05/01/2004 - "A once-daily topical application of a combination of 5% benzoyl peroxide and 1% clindamycin is effective and well tolerated in patients with moderate to severe rosacea."
4.	Hypopigmentation (Hypomelanosis) 11/01/2010 - "A case of progressive macular hypomelanosis successfully treated with benzoyl peroxide plus narrow-band UVB." 01/01/2011 - "The topical combination of benzoyl peroxide 5% and clindamycin 1% is effective in the treatment of progressive macular hypomelanosis." 01/01/2011 - "To evaluate the therapeutic efficacy of the topical combination of benzoyl peroxide 5% and clindamycin 1% associated with sun exposure for the treatment of progressive macular hypomelanosis. " 01/01/2011 - "Efficacy of topical combination of benzoyl peroxide 5% and clindamycin 1% for the treatment of progressive macular hypomelanosis: a randomized, doubleblind, placebo-controlled trial." 11/01/2011 - "Comparison of the clinical efficacy of NBUVB and NBUVB with benzoyl peroxide/clindamycin in progressive macular hypomelanosis."
5.	Erythema 08/01/1983 - "Benzoyl peroxide acetone gel was superior to placebo with respect to improvement in the overall severity of the lesions when judged by photographs, and by reduction of erythema, papules, and pustules. " 08/01/2010 - "Results from three randomized, double-blind, vehicle-controlled, clinical trials of adapalene-benzoyl peroxide were combined in a retrospective meta-analysis that included 909 patients treated for 12 weeks and assessed at each visit for erythema, scaling, dryness, and stinging/burning. " 06/30/2012 - "Forty dogs with clinical signs (pruritus, erythema and excoriations without pustules and/or collarettes) and cytological findings compatible with bacterial overgrowth were treated twice weekly with 3 per cent chlorhexidine shampoo (3 per cent CHX) or 2.5 per cent benzoyl peroxide shampoo (2.5 per cent BPO) and evaluated every two weeks for up to six weeks until cytological cure. " 08/01/2010 - "This could be due to the difficulty in visualizing erythema in patients with darker skin types, mainly Fitzpatrick skin types VI. Acne patients with Fitzpatrick skin types IV to VI were not found to be more susceptible to cutaneous irritation from treatment with the adapalene-benzoyl peroxide gel than patients with Fitzpatrick skin types I to III." 05/01/2004 - "Severity scores for erythema, papules/pustules, and flushing/blushing decreased more with benzoyl peroxide/clindamycin than with vehicle. "

Related Drugs and Biologics

1.	Clindamycin (Cleocin)
2.	adapalene (Differin)
3.	clindamycin-2-phosphate (Clindets)
4.	Tretinoin (Retinoic Acid)
5.	Erythromycin (Erycette)
6.	Isotretinoin (Accutane)
7.	Salicylic Acid (2 Hydroxybenzoic Acid)
8.	Anti-Bacterial Agents (Antibiotics)
9.	tazarotene (Tazorac)
10.	Retinoids

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Aftercare (After-Treatment)
3.	Phototherapy (Light Therapy)
4.	Stents
5.	Prostheses and Implants (Prosthesis)