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The Adenosine A2A Receptor Agonist Accelerates Bone Healing and Adjusts Treg/Th17 Cell Balance through Interleukin 6.

Abstract
The aim of this study was to explore the effect of adenosine A2A receptor agonists on fracture healing and the regulation of the immunity system after bone fracture. We implanted fibrin gel containing adenosine A2A receptor agonist CGS 21680/inhibitor ZM 241385/saline locally in rat tibial fracture models, finding that the adenosine A2A receptor agonist could promote fracture healing. At the same time, the adenosine A2A receptor agonist decreased the level of IL-6 in blood and the fracture area, increased Treg cells, and decreased Th17 cells in blood of bone fracture rats. Further, tibial fracture rats implanted with the adenosine A2A receptor agonist gel were injected with IL-6. We found that IL-6 could reverse the effect of adenosine A2A receptor agonists on fracture healing and Treg/Th17 cells in blood. Through the above results, we believe that the adenosine A2A receptor agonist can promote fracture healing and regulate Treg/Th17 cells in blood of rats with fractures. These effects are related to IL-6.
AuthorsXi Zheng, Dong Wang
JournalBioMed research international (Biomed Res Int) Vol. 2020 Pg. 2603873 ( 2020) ISSN: 2314-6141 [Electronic] United States
PMID32382539 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Xi Zheng and Dong Wang.
Chemical References
  • Adenosine A2 Receptor Agonists
  • Il6 protein, rat
  • Interleukin-6
  • Phenethylamines
  • Receptor, Adenosine A2A
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
  • Adenosine
Topics
  • Adenosine (analogs & derivatives, pharmacology)
  • Adenosine A2 Receptor Agonists (pharmacology)
  • Animals
  • Disease Models, Animal
  • Female
  • Fracture Healing (drug effects, immunology)
  • Interleukin-6 (immunology)
  • Phenethylamines (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Adenosine A2A (immunology)
  • T-Lymphocytes, Regulatory (immunology, pathology)
  • Th17 Cells (immunology, pathology)
  • Tibial Fractures (drug therapy, immunology, pathology)

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