Adenosine A2A Receptor (Adenosine A2A Receptors)

A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

Also Known As:

Networked: 453 relevant articles (31 outcomes, 68 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Linden, Joel: 35 articles (12/2014 - 09/2002)
2.	Chen, Jiang-Fan: 29 articles (12/2015 - 06/2002)
3.	Kron, Irving L: 15 articles (12/2015 - 09/2002)
4.	Cronstein, Bruce N: 15 articles (12/2015 - 02/2002)
5.	Pedata, Felicita: 12 articles (08/2015 - 06/2002)
6.	Schwarzschild, Michael A: 11 articles (08/2013 - 06/2002)
7.	Morelli, Micaela: 11 articles (03/2011 - 06/2002)
8.	Melani, Alessia: 10 articles (08/2015 - 01/2003)
9.	Laubach, Victor E: 9 articles (12/2015 - 11/2002)
10.	Yang, Nan: 8 articles (10/2015 - 04/2008)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 03/01/2011 - "Adenosine A(2A) receptor antagonists are one of the most attractive classes of drug for the treatment of Parkinson's disease (PD) as they are effective in counteracting motor dysfunctions and display neuroprotective and anti-inflammatory effects in animal models of PD. " 03/01/2010 - "Adenosine A(2A) receptor antagonists have emerged as an attractive non-dopaminergic target in clinical trials aimed at evaluating improvement in motor deficits in Parkinson's disease (PD). " 11/01/2006 - "The adenosine A2A receptor has emerged as an attractive non-dopaminergic target in the pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS distribution. " 03/01/2005 - "In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A(2A) receptor has emerged as an attractive nondopaminergic target. " 01/01/2002 - "Since adenosine A2A receptor is selectively localized in striatum for controlling motor activity, it appeared to be an attractive target for a novel treatment in Parkinson's disease. "
2.	Ischemia 01/01/2014 - "Recently, adenosine A(2A) receptor emerged as a potential therapeutic attractive target in ischemia. " 10/01/2010 - "Thus, we compared adenosine A2A receptor knockout (A2AKO) and wild-type mouse hearts (n = 9-11) subjected to global ischemia (30 minutes) and reperfusion (60 minutes) in the presence and absence of the A1 agonist N-cyclopentlyadenosine (CPA). " 06/01/2003 - "Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation." 01/10/2003 - "Adenosine A(2A) receptor antagonists have been proved protective in different ischemia models. " 07/01/2002 - "More recent data have shown that antagonists of adenosine A2A receptors markedly reduce cerebral ischemic damage in animal models of focal and global ischemia. "
3.	Reperfusion Injury 01/01/2008 - "Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion." 02/01/2010 - "This study tests the hypothesis that adenosine A(2A) receptor activation attenuates ischemia-reperfusion injury by inhibiting CD4+ T cell activation and subsequent neutrophil infiltration. " 12/01/2015 - "We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung ischemia-reperfusion injury. " 02/01/2010 - "Adenosine A(2A) receptor activation potently attenuates lung ischemia-reperfusion injury. " 02/01/2010 - "Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury."
4.	Dyskinesias (Dyskinesia) 01/01/2014 - "In this literature review, we will summarize the current knowledge from both clinical and nonclinical studies on the effects of adenosine A2A receptor blockade on dyskinesia." 01/01/2014 - "Clinical/pharmacological aspect of adenosine A2A receptor antagonist for dyskinesia." 12/27/2006 - "Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice." 01/01/2014 - "It has been demonstrated that the expression of adenosine A2A receptors is increased in Parkinson's disease (PD) patients with dyskinesias, suggesting that blockade of A2A receptors is beneficial for dyskinesias. " 05/01/2004 - "Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias."
5.	Wounds and Injuries (Trauma) 04/25/2008 - "Recently, activation of the adenosine A2A receptors has been shown to exert protection against peripheral tissue injuries but aggravation in the central nervous system (CNS) injuries. " 04/01/2008 - "This may provide a new and efficient strategy to study the effect of adenosine A2A receptors in disease and injuries of central nervous system." 05/01/2013 - "We previously demonstrated that the activation of the adenosine A2A receptor promotes epithelial wound closure. " 01/01/2006 - "The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. " 06/01/2004 - "Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis."

Related Drugs and Biologics

1.	istradefylline
2.	5- amino- 7- (2- phenylethyl)- 2- (2- furyl)pyrazolo(4,3- e)- 1,2,4- triazolo(1,5- c)pyrimidine
3.	Levodopa (L Dopa)
4.	Glutamic Acid (Glutamate)
5.	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
6.	Adenosine
7.	P-2 (P 2)
8.	ZM 241385 (ZM241385)
9.	Adenosine-5'-(N-ethylcarboxamide) (NECA)
10.	8-ethoxy- 9-ethyladenine

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics
3.	Debridement
4.	Cardiopulmonary Bypass (Heart-Lung Bypass)
5.	Activities of Daily Living (ADL)