Elderly-onset
rheumatoid arthritis (EORA) and
polymyalgia rheumatica (PMR) are common
rheumatic diseases in older adults.
Oxylipins are bioactive
lipids derived from omega-6 (n-6) and omega-3 (n-3)
polyunsaturated fatty acids (PUFAs) that serve as activators or suppressors of systemic
inflammation. We hypothesized that
arthritis symptoms in older adults were related to
oxylipin-related perturbations.
Arthritis in older adults (ARTIEL) is an observational prospective cohort with 64 patients older than 60 years of age with newly diagnosed
arthritis. Patients' blood samples at baseline and 3 months posttreatment were compared with 18 controls. A thorough clinical examination was conducted. Serum
oxylipins were determined by mass spectrometry. Data processing and statistical analysis were performed in R. Forty-four patients were diagnosed with EORA and 20 with PMR. At diagnosis, EORA patients had a mean DAS28CRP (Disease Activity Score 28 using
C-reactive protein) of 5.77 (SD 1.02). One hundred percent of PMR patients reported
shoulder pain and 90% reported
pelvic pain. Several n-6- and n-3-derived
oxylipin species were significantly different between controls and
arthritis patients. The ratio of n-3/n-6 PUFA was significantly downregulated in EORA but not in PMR patients as compared to controls. The top two candidates as
biomarkers for differentiating PMR from EORA were 4-HDoHE, a hydroxydocosahexaenoic
acid, and 8,15-dihydroxy-eicosatrienoic
acid (8,15-diHETE). The levels of n-3-derived anti-inflammatory species increased in EORA
after treatment. These results suggest that certain
oxylipins may be key effectors in arthrtis in older adults and that the imbalance between n-6- and n-3-derived
oxylipins might be related to pathobiology in this population.