Abstract | BACKGROUND: METHODS: A total of 253 children (122 boys, 131 girls; mean age 12.2 ± 3.6, range 2.9-17.8 years) who underwent endoscopy with biopsies for chronic gastrointestinal symptoms were recruited, except for 38 children diagnosed with inflammatory bowel disease, and divided into EoGID (n = 67) and functional abdominal pain disorder (n = 186). FCal, white blood cell (WBC) counts, eosinophil counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured in all subjects at initial diagnosis. RESULTS: FCal levels weakly correlated with WBC (r = 0.127, P = 0.044) and CRP (r = 0.126, P = 0.040) but not with ESR and eosinophil count. FCal levels were significantly higher in the EoGID group than in the functional abdominal pain disorder group (mean 179.5 ± 242.9 mg/kg vs. 44.3 ± 68.1 mg/kg; P < 0.001), while WBC, ESR, CRP, and eosinophil count did not differ between the two groups (all P > 0.05). An optimal cutoff of FCal 73.2 mg/kg distinguished EoGID from functional abdominal pain disorder with a sensitivity of 50.7% and a specificity of 84.6%. CONCLUSION: FCal is a useful and reliable noninvasive marker for differentiating EoGID from functional abdominal pain disorder in Korean children with chronic gastrointestinal symptoms when optimal cutoffs are applied.
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Authors | In Hyuk Yoo, Jin Min Cho, Jung Yeon Joo, Hye Ran Yang |
Journal | Journal of Korean medical science
(J Korean Med Sci)
Vol. 35
Issue 17
Pg. e120
(May 04 2020)
ISSN: 1598-6357 [Electronic] Korea (South) |
PMID | 32356420
(Publication Type: Journal Article)
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Copyright | © 2020 The Korean Academy of Medical Sciences. |
Chemical References |
- Biomarkers
- Leukocyte L1 Antigen Complex
- C-Reactive Protein
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Topics |
- Abdominal Pain
(etiology)
- Adolescent
- Area Under Curve
- Biomarkers
(analysis)
- C-Reactive Protein
(analysis)
- Child
- Child, Preschool
- Eosinophils
(cytology)
- Feces
(chemistry)
- Female
- Humans
- Inflammatory Bowel Diseases
(complications, diagnosis)
- Intestinal Mucosa
(pathology)
- Leukocyte Count
- Leukocyte L1 Antigen Complex
(analysis)
- Male
- ROC Curve
- Republic of Korea
- Retrospective Studies
- Sensitivity and Specificity
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