Abstract | BACKGROUND: METHODS: RESULTS: The incidence of delirium was 39% (551 of 1,396) among patients who were treated preoperatively with angiotensin system inhibitors and 39% (1,344 of 3,468) in patients who were not. The adjusted odds ratio of experiencing delirium during critical care was 0.98 (95% CI, 0.86 to 1.10; P = 0.700) for preoperative use of angiotensin system inhibitors versus control. Delirium was observed in 23% (100 of 440) of patients who used angiotensin system inhibitors postoperatively before intensive care discharge, and in 41% (1,795 of 4,424) of patients who did not (unadjusted P < 0.001). The confounder-adjusted odds ratio for experiencing delirium in patients who used angiotensin system inhibitors postoperatively was 0.55 (95% CI, 0.43 to 0.72; P < 0.001). CONCLUSIONS:
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Authors | Ehab Farag, Chen Liang, Edward J Mascha, Maged Y Argalious, Jacob Ezell, Kamal Maheshwari, Wael Ali Sakr Esa, Christopher A Troianos, Daniel I Sessler |
Journal | Anesthesiology
(Anesthesiology)
Vol. 133
Issue 1
Pg. 119-132
(07 2020)
ISSN: 1528-1175 [Electronic] United States |
PMID | 32349070
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Benzodiazepines
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Topics |
- Aged
- Angiotensin II Type 1 Receptor Blockers
(adverse effects)
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects)
- Antihypertensive Agents
(adverse effects)
- Benzodiazepines
(adverse effects)
- Cohort Studies
- Confusion
(etiology, psychology)
- Critical Care
- Emergence Delirium
(chemically induced, epidemiology, prevention & control)
- Female
- Humans
- Incidence
- Length of Stay
- Male
- Middle Aged
- Negative Results
- Propensity Score
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