Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the
nuclear receptor superfamily, participates in multiple physiological and
pathological processes. Extensive studies have revealed the relationship between PPARγ and various
tumors. However, the expression and function of PPARγ in
bladder cancer seem to be controversial. It has been demonstrated that PPARγ affects the occurrence and progression of
bladder cancer by regulating proliferation, apoptosis,
metastasis, and
reactive oxygen species (ROS) and lipid metabolism, probably through PPARγ-SIRT1 feedback loops, the PI3K-Akt signaling pathway, and the WNT/β-
catenin signaling pathway. Considering the frequent relapses after
chemotherapy, some researchers have focused on the relationship between PPARγ and
chemotherapy sensitivity in
bladder cancer. Moreover, the feasibility of PPARγ
ligands as potential therapeutic targets for
bladder cancer has been uncovered. Taken together, this review summarizes the relevant literature and our findings to explore the complicated role and function of PPARγ in
bladder cancer.