Abstract | BACKGROUND: Studies of long-term inotrope use in advanced HF have previously provided limited and conflicting results. This study aimed to evaluate the safety and efficacy of long-term milrinone use and identify predictors of failure to bridge to orthotropic heart transplant (OHT) in a cohort of end-stage heart failure (HF) patients listed for heart transplantation and receiving inotrope therapy. METHODS: The study included 150 adults listed for OHT at a single center from 2001 to 2017 who received milrinone therapy for ≥30 days. Multivariate Cox proportional hazards models were used to identify factors associated with "failure" (left ventricular assist device, intra-aortic balloon pump, status downgrade due to instability, death) vs. "success" (OHT, recovery) during bridging to OHT. RESULTS: CONCLUSIONS: Our findings suggest that long-term milrinone therapy in selected patients is associated with a high rate of successful bridging to OHT and a low rate of adverse events. Patients intolerant of GDMT are more likely to fail to bridge to OHT without mechanical support. Sex differences in outcomes associated with milrinone therapy should be explored.
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Authors | Elizabeth C Lee, Scott McNitt, John Martens, Jeffrey T Bruckel, Leway Chen, Jeffrey D Alexis, Eugene Storozynsky, Sabu Thomas, Igor Gosev, Bryan Barrus, Ilan Goldenberg, Himabindu Vidula |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 313
Pg. 83-88
(08 15 2020)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 32320777
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Female
- Heart Failure
(diagnosis, drug therapy)
- Heart Transplantation
- Heart-Assist Devices
- Humans
- Male
- Milrinone
(adverse effects)
- Retrospective Studies
- Treatment Outcome
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