Lipoprotein(a) concentration is associated with risk of type 2 diabetes and cardiovascular events in a Chinese population with very high cardiovascular risk.

Abstract

PURPOSE:

Evidences have shown that elevated lipoprotein(a) [Lp(a)] levels were associated with a lower risk of type 2 diabetes, but a higher risk of cardiovascular events in general populations. We aim to demonstrate the effect of Lp(a) concentrations on type 2 diabetes and cardiovascular events in a Chinese population with very high cardiovascular risk.

METHODS:

Seven hundred ninety-eight participants who underwent coronary angiography between March and November 2013 with normal glucose metabolism were followed up from July to December 2018.

RESULTS:

Five hundred thirty-five participants completed follow-up, and 395 of them had blood glucose data. Among 395 participants with blood glucose data, a total of 28 incident type 2 diabetes were identified during a median follow-up period of 4.42 years. Compared with the patients in the lowest tertile of Lp(a), the multifactorial adjusted HR for type 2 diabetes was 0.29 in the highest tertile (95% confidence intervals (CI) 0.10-0.89; P for trend = 0.03). Among 535 patients who completed follow-up, a total of 80 cases of major adverse cardiovascular events (MACE) were identified during a median follow-up period of 5.08 years. Compared with the patients in the lowest tertile of Lp(a), the multifactorial adjusted HR for MACE was 1.95 in the highest tertile (95% CI 1.05-3.65; P for trend = 0.03).

CONCLUSIONS:

Elevated Lp(a) levels were associated with a lower risk of type 2 diabetes, but a higher risk of cardiovascular events in a Chinese population with very high cardiovascular risk.

• Authors: Dilidaer Muhanhali, Tianyu Zhai, Zhenqin Cai, Yan Ling
• Journal: Endocrine (Endocrine) Vol. 69 Issue 1 Pg. 63-72 (07 2020) ISSN: 1559-0100 [Electronic] United States
• PMID: 32253681 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Lipoprotein(a)

Topics

• Biomarkers
• Cardiovascular Diseases (epidemiology, etiology)
• China (epidemiology)
• Diabetes Mellitus, Type 2 (epidemiology)
• Heart Disease Risk Factors
• Humans
• Lipoprotein(a)
• Risk Factors