Acute
Myocardial Infarction (MI) is one of the foremost causes of human death worldwide and it leads to mass death of cardiomyocytes, interchanges of unfavorable biological environment and affecting electrical communications by
fibrosis scar formations, and specifically deficiency of blood supply to heart which leads to heart damage and
heart failure. Recently, numerous appropriate strategies have been applied to base on solve these problems
wound be provide prominent therapeutic potential to cardiac regeneration after acute MI. In the present study, a combined biopolymeric conductive
hydrogel was fabricated with conductive ultra-small
graphene quantum dots as a soft
injectable hydrogel for cardiac regenerations. The resultant
hydrogel was combined with human Mesenchymal stem cells (hMSCs) to improved angiogenesis in cardiovascular tissues and decreasing cardiomyocyte
necrosis of
hydrogel treated acute-infarcted region has been greatly associated with the development of cardiac functions in MI models. The prepared
graphene quantum dots and
hydrogel groups was physico-chemically analyzed and confirmed the suitability of the materials for cardiac regeneration applications. The in vitro analyzes of
hydrogels with hMSCs have established that enhanced cell survival rate, increased expressions of pro-inflammatory factors, pro-angiogenic factors and early cardiogenic markers. The results of in vivo myocardial observations and electrocardiography data demonstrated a favorable outcome of ejection fraction,
fibrosis area, vessel density with reduced
infarction size, implying that significant development of heart regenerative function after MI. This novel strategy of
injectable hydrogel with hMSCs could be appropriate for the effective treatment of cardiac
therapies after acute MI.