Effects of Estrogen on Cardiac mRNA and LncRNA Expression Profiles in Hypertensive Mice.

Abstract

Estrogen is a vascular protection factor and plays a protective role in the pathogenesis of gender differences in cardiovascular diseases. This study was to address the possible mechanisms that may explain the relationship between estradiol configuration-17β-estradiol (E2) and ventricular remodeling. Here, we show that a total of 1499 LncRNAs and 680 mRNAs significantly differently expressed were identified. This result indicates that estradiol has a global role in regulating heart gene expression profiles in female mice. Go and Pathway functional cluster analysis showed that the antagonism of E2 on cardiac remodeling and AngII-induced pathological changes in female mice may be related to physiological processes such as circadian rhythm disorder and ion channel dysfunction. Graphical Abstract.

• Authors: Jingkang Zhu, Huan Wang, Hui Chen
• Journal: Journal of cardiovascular translational research (J Cardiovasc Transl Res) Vol. 14 Issue 4 Pg. 706-727 (08 2021) ISSN: 1937-5395 [Electronic] United States
• PMID: 32236843 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• RNA, Long Noncoding
• RNA, Messenger
• Angiotensin II
• Estradiol

Topics

• Angiotensin II
• Animals
• Blood Pressure (drug effects, genetics)
• Disease Models, Animal
• Estradiol (administration & dosage)
• Estrogen Replacement Therapy
• Female
• Gene Expression Profiling
• Hypertension (chemically induced, genetics, metabolism, physiopathology)
• Mice, Inbred C57BL
• Myocytes, Cardiac (drug effects, metabolism)
• Ovariectomy
• Oxidative Stress (drug effects, genetics)
• RNA, Long Noncoding (genetics, metabolism)
• RNA, Messenger (genetics, metabolism)
• Transcriptome
• Ventricular Remodeling (drug effects, genetics)
• Mice