Effects of dietary dihydroartemisinin supplementation on growth performance, hepatic inflammation, and lipid metabolism in weaned piglets with intrauterine growth retardation.

Abstract

The aims of this study were to investigate the effects of dietary supplementation with dihydroartemisinin (DHA) on growth performance, hepatic inflammation, and lipid metabolism in intrauterine growth retardation (IUGR)-affected weaned piglets. Eight piglets with normal birth weight (NBW) and 16 IUGR-affected piglets were selected and fed either a basal diet (NBW and IUGR groups) or the basal diet supplemented with 80 mg/kg DHA (IUGR-DHA group) from 21 to 49 day of age. Blood and liver samples were collected on day 49. DHA supplementation significantly alleviated the compromised growth performance and liver damage in IUGR-affected piglets. Additionally, DHA supplementation decreased the activities of alanine aminotransferase and aspartate aminotransferase, as well as the serum levels of non-esterified fatty acids (NEFA), very-low-density lipoprotein, and total cholesterol. In the liver, the concentrations of interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, triglycerides, and NEFA were decreased. Fatty acid synthesis was decreased by DHA supplementation, whereas the activities of lipoprotein lipase, hepatic lipase, and total lipase were increased. Dietary DHA supplementation led to upregulation of the expression of AMPK/SIRT1 signaling pathway-related genes, whereas that of inflammatory factor-related genes were downregulated. In conclusion, dietary inclusion of 80 mg/kg DHA can alleviate IUGR-induced impairments in piglets.

• Authors: Yongwei Zhao, Yu Niu, Jintian He, Zhending Gan, Shuli Ji, Lili Zhang, Chao Wang, Tian Wang
• Journal: Animal science journal = Nihon chikusan Gakkaiho (Anim Sci J) 2020 Jan-Dec Vol. 91 Issue 1 Pg. e13363 ISSN: 1740-0929 [Electronic] Australia
• PMID: 32219939 (Publication Type: Journal Article)
• Copyright: © 2020 Japanese Society of Animal Science.

Chemical References

• Artemisinins
• Fatty Acids, Nonesterified
• artenimol
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Alanine Transaminase (metabolism)
• Animals
• Artemisinins (administration & dosage, pharmacology)
• Aspartate Aminotransferases (metabolism)
• Diet (veterinary)
• Dietary Supplements
• Fatty Acids, Nonesterified (metabolism)
• Female
• Fetal Growth Retardation (metabolism, pathology, veterinary)
• Inflammation (drug therapy, veterinary)
• Lipid Metabolism (drug effects)
• Liver (pathology)
• MAP Kinase Signaling System (drug effects, genetics)
• Pregnancy
• Swine (growth & development, metabolism)
• Swine Diseases (metabolism)
• Weaning