Glucose challenge metabolomics implicates the change of organic acid profiles in hyperlipidemic subjects.

Abstract

Hyperlipidemia (HLP) is a major risk factor of diabetes and cardiovascular disease. Here, we applied gas chromatography-mass spectrometry to study differences in postprandial organic acid profiles in healthy and HLP subjects. In fasting status, six intermediates of the tricarboxylic acid cycle showed significant differences in HLP and healthy controls (P < 0.05). The percentage changes of 17 metabolites including three intermediates of the tricarboxylic acid cycle were significantly different during the oral glucose tolerance test. Postprandial changes in ethylmalonic acid and pimelic acid were negatively associated with HOMA-IR (homeostasis model assessment of insulin resistance; all P < 0.05) in the HLP group. Postprandial metabolism of organic acid profiles revealed energy metabolism perturbations in HLP. Our findings provide new insights into the complex physiological regulation of HLP postprandial metabolism.

• Authors: Xiaowei Liu, Jiaying Yu, Jinhui Zhao, Jing Guo, Mingjia Zhang, Liyan Liu
• Journal: Biomedical chromatography : BMC (Biomed Chromatogr) Vol. 34 Issue 6 Pg. e4815 (Jun 2020) ISSN: 1099-0801 [Electronic] England
• PMID: 32115742 (Publication Type: Journal Article)
• Copyright: © 2020 John Wiley & Sons, Ltd.

Chemical References

• Carboxylic Acids
• Glucose

Topics

• Adult
• Carboxylic Acids (blood, metabolism)
• Female
• Gas Chromatography-Mass Spectrometry
• Glucose (administration & dosage, metabolism)
• Glucose Tolerance Test
• Humans
• Hyperlipidemias (metabolism)
• Insulin Resistance (physiology)
• Male
• Metabolome (physiology)
• Metabolomics
• Middle Aged
• Postprandial Period (physiology)