The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.

Abstract

OBJECTIVES:

The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.

METHODS:

Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of asprosin, leptin, glucose and lipid profile were investigated.

RESULTS:

Irisin infusion increased asprosin levels in male rats (p = .02) but not in female rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) and leptin levels in all groups; however, it did not lead to any change in asprosin levels in both obese female and male rats.

CONCLUSIONS:

It was determined that irisin increased serum asprosin levels and decreased LDL, TG, glucose and leptin levels, and this could indicate a protective role of irisin against obesity development.

• Authors: Sibel Ozcan, Nazife Ulker, Ozgur Bulmus, Ahmet Yardimci, Mete Ozcan, Sinan Canpolat
• Journal: Archives of physiology and biochemistry (Arch Physiol Biochem) Vol. 128 Issue 3 Pg. 724-731 (Jun 2022) ISSN: 1744-4160 [Electronic] England
• PMID: 32027180 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Fibrillin-1
• Fibronectins
• Leptin
• Lipids
• Peptide Hormones
• Triglycerides
• asprosin peptide, rat

Topics

• Animals
• Blood Glucose
• Female
• Fibrillin-1 (blood)
• Fibronectins (pharmacology)
• Leptin (blood)
• Lipids (blood)
• Male
• Obesity (blood, drug therapy)
• Peptide Hormones (blood)
• Rats
• Triglycerides (blood)