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Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury.

Abstract
Red blood cells (RBCs) play an important role in the cardiac ischemia/reperfusion (I/R) injury. Cardiovascular risk factors impair the RBC function in an endothelial nitric oxide synthase (eNOS) dependent manner. However, it is unclear whether the protective role of RBCs can be rescued by modifying cardiovascular risk factors or by pharmacologic intervention. RBCs obtained from elderly patients with or without diabetes as well as from young volunteers were treated with vehicle, eNOS inhibitor l-NAME and/or arginase inhibitor nor-NOHA before loading to the coronary system of isolated murine hearts in a Langendorff system before 40 min of global ischemia. RBCs from young and healthy volunteers as well as from aged persons and elderly diabetes patients with satisfying blood glucose control improved left ventricular function upon 60 min of reperfusion with Krebs-Henseleit buffer and reduced the infarct size compared to buffer treated controls. This cardioprotective effect was abolished in RBCs from aged diabetes patients with poor blood glucose control. Treatment of RBCs from elderly diabetes patients with nor-NOHA partly rescued the cardioprotective function. Thus, effective glucose control in aged diabetes patients rescues RBC-dependent cardioprotection in an ex-vivo model of myocardial I/R injury.
AuthorsJohanna M Muessig, Luise Moellhoff, Johanna Noelle, Sema Kaya, Leonie Hidalgo Pareja, Maryna Masyuk, Michael Roden, Malte Kelm, Christian Jung
JournalNitric oxide : biology and chemistry (Nitric Oxide) Vol. 97 Pg. 1-10 (04 01 2020) ISSN: 1089-8611 [Electronic] United States
PMID31981741 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2020 Elsevier Inc. All rights reserved.
Chemical References
  • Blood Glucose
Topics
  • Adult
  • Animals
  • Blood Glucose (metabolism)
  • Erythrocytes (metabolism)
  • Female
  • Humans
  • Male
  • Mice
  • Myocardial Reperfusion Injury (metabolism, therapy)
  • Risk Factors
  • Young Adult

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