Abstract | OBJECTIVE: METHODS:
Cerebral ischemia was induced in swiss albino mice by performing BCCAO surgery. Morris water-maze test was utilized to assess the learning ability and memory of the animals. The whole brain acetylcholinesterase (AChE) activity, TBARS, GSH levels and MPO activity were evaluated as the biochemical parameters. For histopathological evaluation of the cerebral infarct size, TTC staining was employed. RESULTS: Administration of L-carnosine (500 mg/kg, i.p.) successfully attenuated the manifestations of cerebral ischemia. Higher levels of AChE, TBARS, and MPO were observed in BCCAO treated animals, which were successfully attenuated by treatment with L-carnosine and ischemic postconditioning. Whereas administration of L-carnosine and ischemic postconditioning significantly increased the level of GSH in BCCAO treated animals. Moreover, treatment with ranitidine, an H2 blocker (30 NMol, i.c.v) antagonized the neuroprotective actions of L-carnosine evidenced by decrease in MWM performance, increase in the level of AChE and oxidative stress, while decrease in GSH level in brain. The cerebral infarct size was found to be more in BCCAO inflicted animals, which was improved by the administration of L-carnosine, while the cerebral infarct size worsened by treatment with ranitidine (3 nmol, i.c.v.). CONCLUSION:
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Authors | Jasleen Kaur Virdi, Amritansh Bhanot, Amteshwar Singh Jaggi, Neha Agarwal |
Journal | The International journal of neuroscience
(Int J Neurosci)
Vol. 130
Issue 10
Pg. 983-998
(Oct 2020)
ISSN: 1563-5279 [Electronic] England |
PMID | 31951767
(Publication Type: Journal Article)
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Chemical References |
- Histamine H2 Antagonists
- Neuroprotective Agents
- Histidine
- Histamine
- Carnosine
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Topics |
- Animals
- Brain Ischemia
(drug therapy, metabolism, therapy)
- Carnosine
(administration & dosage, pharmacology)
- Histamine
(metabolism)
- Histamine H2 Antagonists
(pharmacology)
- Histidine
(metabolism)
- Ischemic Postconditioning
- Male
- Maze Learning
(physiology)
- Mice
- Neuroprotective Agents
(administration & dosage, pharmacology)
- Signal Transduction
(drug effects)
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