[Severe Thrombocitopenia Induced by Fenofibrate].

Abstract

Drug-induced thrombocytopenia is a common entity in clinical practice. However, having in consideration the severity of the case, it becomes imperative to distinguish non-immune thrombocytopenia from the po-tentially life-threatening immune-mediated forms. The authors report a rare clinical case of a 79-year-old man presenting with purpuric rash and gingival hemorrhage while on fenofibrate treatment (sixth day). The evolu-tion was favorable after drug removal and corticosteroid administration. Drug-associated thrombocytopenia is reported by manufacturers as an extremely rare event. This is the second case report of immune throm-bocytopenia to fenofibrate. The first event was reported for publication in 2015.

• Authors: Ana Clara, Tiago Martins, Alexandra Martins, Ana Baptista, Mário Lázaro
• Journal: Acta medica portuguesa (Acta Med Port) Vol. 33 Issue 1 Pg. 58-61 (Jan 03 2020) ISSN: 1646-0758 [Electronic] Portugal
• Vernacular Title: Trombocitopenia Grave Induzida por Fenofibrato.
• PMID: 31928604 (Publication Type: Case Reports)

Chemical References

• Glucocorticoids
• Hypolipidemic Agents
• Fenofibrate
• Methylprednisolone

Topics

• Aged
• Fenofibrate (adverse effects)
• Glucocorticoids (therapeutic use)
• Humans
• Hypolipidemic Agents (adverse effects)
• Male
• Methylprednisolone (therapeutic use)
• Purpura, Thrombocytopenic (chemically induced, drug therapy)