Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction.

Abstract

Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI.Materials and methods: Twenty TTC patients were matched with 40 STEMI patients by age, gender and left ventricular ejection fraction. Blood was sampled upon hospital admission immediately before acute coronary angiography.Results: The groups had similar comorbidities. TTC patients had higher plasma concentrations of sTM: 7.94 (5.89;9.61) vs. 6.42 (5.50;7.82)ng/ml, p = 0.04 and ST2 (53 (32;157) vs. 45 (31;55)ng/ml, p = 0.008) and higher heart rate: 101 ([Formula: see text]33) vs. 76([Formula: see text]14)bpm, p = 0.0001, but lower concentrations of copeptin (10.4 (7.6;39) vs. 92.3 (13;197)pmol/l, p < 0.05) and troponin T (348 (98;759) vs. 1190 (261;4105)ng/l, p = 0.04).Conclusion: TTC patients had higher plasma concentrations of sTM and ST2, higher heart rate and lower copeptin and troponin T concentrations compared to acute anterior STEMI patients. This study contributes to the hypothesis that TTC patients have endothelial cell damage and are hemodynamically more stable than patients with acute anterior STEMI on admission.

• Authors: Mathias Alexander Højagergaard, Christian Hassager, Thomas Emil Christensen, Lia Evi Bang, Jens Peter Gøtze, Sisse Rye Ostrowski, Lene Holmvang, Martin Frydland
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 25 Issue 2 Pg. 137-143 (Mar 2020) ISSN: 1366-5804 [Electronic] England
• PMID: 31902247 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Glycopeptides
• IL1RL1 protein, human
• Interleukin-1 Receptor-Like 1 Protein
• Thrombomodulin
• Troponin T
• copeptins

Topics

• Aged
• Biomarkers (blood)
• Diagnosis, Differential
• Endothelial Cells (pathology)
• Female
• Glycopeptides (blood)
• Heart Rate
• Hemodynamics
• Humans
• Interleukin-1 Receptor-Like 1 Protein (blood)
• Male
• Middle Aged
• ST Elevation Myocardial Infarction (blood, diagnosis)
• Takotsubo Cardiomyopathy (blood, diagnosis)
• Thrombomodulin (blood)
• Troponin T (blood)