Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients.

Abstract

PURPOSE:

Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea.

METHODS:

Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea-hypopnea index ≥ 5/h.

RESULTS:

PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8-40.8 ng/ml) and patients with OSA (19.6/8.4-56.8, p = 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4-56.8 ng/ml) compared to mild OSA patients (14.1/8.5-35.3 ng/ml, p = 0.006) and controls (p = 0.03).

CONCLUSIONS:

P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.

• Authors: P Horváth, Z Lázár, G Gálffy, R Puskás, L Kunos, Gy Losonczy, M Mészáros, Á D Tárnoki, D L Tárnoki, A Bikov
• Journal: Lung (Lung) Vol. 198 Issue 1 Pg. 173-179 (02 2020) ISSN: 1432-1750 [Electronic] United States
• PMID: 31897593 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Membrane Glycoproteins
• P-Selectin
• P-selectin ligand protein

Topics

• Adult
• Aged
• Case-Control Studies
• Female
• Humans
• Inflammation
• Male
• Membrane Glycoproteins (blood)
• Middle Aged
• P-Selectin (blood)
• Polysomnography
• Sleep Apnea, Obstructive (blood)