Abstract | BACKGROUND & OBJECTIVE: METHODS: The pharmacokinetics, acute toxicity, and tissue distribution were determined in C57BL/6 male and female mice after the intraperitoneal administration of a single dose. Behavioral tests, as well as investigations of brain atrophy and white matter injury, were used to evaluate the neuroprotective effect of Scriptaid after ICH. Western blotting was used to investigate if Scriptaid could offer antiinflammatory benefits after ICH. RESULTS: No significant differences were observed in body weight or brain histopathology between the group that received Scriptaid at 50 mg/kg and the group that received dimethyl sulfoxide (control). The pharmacokinetics of Scriptaid in mice was nonlinear, and it was cleared rapidly at low doses and slowly at higher doses. Consistent with the pharmacokinetic data, Scriptaid was found to distribute in several tissues, including the spleen and kidneys. In the ICH model, we found that Scriptaid could reduce neurological deficits, brain atrophy, and white matter injury in a dose-dependent manner. Western blotting results demonstrated that Scriptaid could decrease the expression of pro-inflammatory cytokines IL1β and TNFα, as well as iNOS, after ICH. CONCLUSION:
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Authors | Heng Yang, Xinjie Gao, Jiabin Su, Hanqiang Jiang, Yu Lei, Wei Ni, Yuxiang Gu |
Journal | CNS & neurological disorders drug targets
(CNS Neurol Disord Drug Targets)
Vol. 19
Issue 1
Pg. 55-65
( 2020)
ISSN: 1996-3181 [Electronic] United Arab Emirates |
PMID | 31858907
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Histone Deacetylase Inhibitors
- Hydroxylamines
- Neuroprotective Agents
- Quinolines
- scriptaid
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Topics |
- Animals
- Brain
(drug effects)
- Disease Models, Animal
- Female
- Histone Deacetylase Inhibitors
(pharmacokinetics, therapeutic use, toxicity)
- Hydroxylamines
(pharmacokinetics, therapeutic use, toxicity)
- Intracranial Hemorrhages
(drug therapy)
- Male
- Mice
- Mice, Inbred C57BL
- Neuroprotection
(drug effects)
- Neuroprotective Agents
(therapeutic use)
- Quinolines
(pharmacokinetics, therapeutic use, toxicity)
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