Abstract | BACKGROUND: It is imperative to develop markers for risk stratification and detection of cardiometabolic comorbidities in children with obesity. The adipokines leptin and adiponectin are both involved in fat mass regulation and the development of obesity-related disorders; furthermore, their ratio ( leptin/ adiponectin ratio) is suggested to be associated with insulin resistance and cardiometabolic risk. OBJECTIVE: METHODS: A total of 2258 children with overweight/ obesity or normal weight aged 6 to 18 years were studied. Differences in anthropometrics and adipokine concentrations were tested using Wilcoxon rank-sum test. Associations between the adipokines and cardiometabolic risk were tested using Spearman's correlation and logistic regression, adjusted for age and body mass index SD score (BMI-SDS). RESULTS: Compared to normal weight children; children with overweight/ obesity exhibited higher leptin concentrations, lower adiponectin concentrations, and higher L/A ratios. After adjusting for age and degree of obesity, girls with overweight/ obesity in the upper quartile range for the L/A ratio, when compared with girls in the lower quartile range, were more likely to have insulin resistance (odds ratio [OR]: 7.78 [95% confidence interval [CI], 3.78-16.65]), dysglycemia (OR: 3.08 [95% CI, 1.35-7.31]), and dyslipidemia (OR: 2.53 [95% CI, 1.18-5.59]); while boys were more likely to have insulin resistance (OR: 4.45 [95% CI, 2.03-10.10]). CONCLUSIONS:
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Authors | Christine Frithioff-Bøjsøe, Morten A V Lund, Ulrik Lausten-Thomsen, Paula L Hedley, Oluf Pedersen, Michael Christiansen, Jennifer L Baker, Torben Hansen, Jens-Christian Holm |
Journal | Pediatric diabetes
(Pediatr Diabetes)
Vol. 21
Issue 2
Pg. 194-202
(03 2020)
ISSN: 1399-5448 [Electronic] Denmark |
PMID | 31845423
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Adiponectin
- Biomarkers
- Leptin
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Topics |
- Adiponectin
(blood)
- Adolescent
- Biomarkers
(blood)
- Child
- Cohort Studies
- Female
- Humans
- Insulin Resistance
- Leptin
(blood)
- Male
- Pediatric Obesity
(blood)
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