Abstract | BACKGROUND: METHODS: This retrospective and observational clinical study included patients who received CHOP or R- CHOP regimen as initiating chemotherapy between July 2010 and March 2016 (N = 39). Patients were assigned to an aprepitant [ aprepitant (125 mg on day 1, 80 mg on days 2-3) plus granisetron (3 mg); n = 15] or control regimen group [ granisetron (3 mg); n = 24]. Complete response (CR), defined as no vomiting and no use of rescue therapy during overall phase (0-120 h), was the primary endpoint. Secondary endpoints included the time to first vomiting and using rescue medication and complete protection (CP) defined as no vomiting and no retching and/or no nausea and no rescue therapy. The patient records were investigated, and data were retrospectively analyzed. RESULTS: CR rate CP rates did not significantly differ between the groups during the observation period (80.0% versus 83.3%, p = 1.000; and 80.0% versus 79.2%, p = 1.000, respectively). Additionally, the time to first vomiting and using rescue medication in did not significantly differ between the groups (p = 0.909). CONCLUSIONS:
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Authors | Yoshinori Wakasugi, Satoshi Noda, Yoshihiro Ikuno, Miya Horie, Katsuyuki Kito, Hitoshi Minamiguchi, Tomohiro Terada |
Journal | Journal of pharmaceutical health care and sciences
(J Pharm Health Care Sci)
Vol. 5
Pg. 24
( 2019)
ISSN: 2055-0294 [Print] England |
PMID | 31832222
(Publication Type: Journal Article)
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Copyright | © The Author(s). 2019. |