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Granisetron (Kytril)

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A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

Also Known As:

Kytril; 1-Methyl-N-(endo-9-Methyl-9-Azabicyclo(3.3.1)non-3-yl)-1H-Indazole-3-Carboxamide; BRL-43694; BRL-43694A; Granisetron Hydrochloride; Granisetron Monohydrochloride; BRL 43694; BRL 43694A; BRL43694; BRL43694A; Hydrochloride, Granisetron; Monohydrochloride, Granisetron; 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo-

Networked: 717 relevant articles (231 outcomes, 241 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Fujii, Yoshitaka: 16 articles (12/2011 - 03/2002)
2.	Miller, Donald R: 11 articles (12/2012 - 12/2012)
3.	Fujii, Y: 10 articles (06/2001 - 01/2000)
4.	Tanaka, Hiroyoshi: 8 articles (01/2006 - 05/2002)
5.	Tanaka, H: 8 articles (06/2001 - 01/2000)
6.	Cooper, William: 4 articles (09/2015 - 01/2015)
7.	O'Boyle, Erin: 4 articles (09/2015 - 01/2015)
8.	Boccia, Ralph: 4 articles (09/2015 - 01/2015)
9.	Ernberg, Malin: 4 articles (01/2015 - 02/2003)
10.	Gan, Tong J: 4 articles (11/2009 - 01/2005)

Related Diseases

1.	Vomiting 08/01/2012 - "The efficacy of granisetron was measured on each day using the complete regression(no vomiting and no rescue medication; CR)rate. " 09/01/1997 - "The percentage of emesis-free patients was significantly greater in the 5- to 20-microg/kg granisetron groups than in the control and 2-microg/kg granisetron groups (18%, 23%, 68%, 78%, and 75% of patients receiving saline or granisetron 2 microg/kg, 5 microg/kg, 10 microg/kg, and 20 microg/kg, respectively). " 08/01/2003 - "Additionally, incremental doses of granisetron (up to 9 mg) have been shown to be effective and well tolerated in patients with refractory emesis. " 01/01/1994 - "The efficacy of Granisetron, a new and selective 5HT3-receptor-antagonist in the treatment of cytostatic induced emesis, was tested in the department of gynaecology and obstetrics of the University of Essen on 77 patients. " 11/15/1995 - "However, the addition of corticosteroid to orally administered granisetron improved the control of delayed emesis. "
2.	Nausea 04/01/1995 - "Granisetron proved significantly effective in preventing nausea, as 75% of granisetron-administered patients experienced either only slight nausea or none at all, against only 22.5% in the non-granisetron group. " 12/01/1998 - "The study demonstrated that Granisetron is more active than placebo in controlling nausea (3 cases vs 4), and retching (2 vs 6). " 09/01/1997 - "Granisetron doses of 5 microg/kg or larger were also superior to the saline and 2-microg/kg granisetron treatment for the prevention of nausea over the 24-h study period (nausea visual analog scales 24 h after surgery: 49, 41, 18, 16, and 14 mm in the control and granisetron 2 microg/kg, 5 microg/kg, 10 microg/kg, and 20 microg/kg groups, respectively). " 05/01/1995 - "Granisetron at both doses also was superior to the control for the prevention of nausea over the 24-h study period (nausea visual analog scales at 24-h postsurgery: 49 mm, 17 mm, and 18 mm in the control, granisetron 20 micrograms/kg, and granisetron 40 micrograms/kg groups, respectively). " 04/01/2014 - "On the basis of the results of multivariate analysis, young age, female gender, and the use of granisetron were significant risk factors for delayed nausea. "
3.	Postoperative Nausea and Vomiting (PONV) 02/01/1998 - "Granisetron is highly effective for reducing the incidence of PONV in female patients undergoing breast surgery. " 07/01/1998 - "This study was designed to evaluate the efficacy of granisetron administered orally for preventing PONV in female patients undergoing major gynaecological surgery. " 01/01/2012 - "Efficacy of Generic Granisetron vs Kytril® for PONV in Major Gynecological Operations: A Randomized, Double-blind Clinical Trial." 03/01/2001 - "Preoperative oral granisetron, in doses of more than 2 mg, is effective for the prevention of postoperative nausea and vomiting in women undergoing general anaesthesia for breast surgery." 09/01/1998 - "We conclude that preoperative oral granisetron, in doses more than 40 micrograms kg-1, was effective for the prevention of postoperative vomiting in children."
4.	Neoplasms (Cancer) 07/01/1995 - "The safety and efficacy of the new 5HT-3 antagonist granisetron as an antiemetic in children with cancer was evaluated in 40 children at a single dose of 40 micrograms/kg. No adverse affects attributable to the granisetron were noted. " 10/01/2005 - "To compare the efficacy of anti-emetic and prophylactic effects of 1 milligram (mg) versus 3 mg granisetron in cancer patients. " 12/01/1993 - "[Antiemetic efficacy of granisetron in pediatric cancer treatment--(2). " 10/01/2007 - "Few trials have been conducted to determine the optimal effective dose of granisetron in children with cancer. " 08/01/1999 - "This multi-center open study was conducted to study the efficacy, safety and usefulness of granisetron in children with cancer. "
5.	Strabismus (Squint) 01/01/1999 - "Oral granisetron for strabismus surgery in children." 09/01/1999 - "Preoperative oral granisetron, in doses more than 40 microg/kg, is effective for preventing vomiting after strabismus surgery in children." 09/01/1999 - "To evaluate the efficacy of oral granisetron for the prevention of postoperative vomiting in children undergoing strabismus surgery. " 01/01/1999 - "To determine the efficacy of oral granisetron in preventing postoperative vomiting (POV) following strabismus repair in children. " 09/01/1999 - "Preoperative oral granisetron for the prevention of vomiting after strabismus surgery in children."

Related Drugs and Biologics

1.	Dexamethasone (Maxidex)
2.	Ondansetron (Zofran)
3.	Droperidol
4.	Metoclopramide (Reglan)
5.	Cisplatin (Platino)
6.	Serotonin (5 Hydroxytryptamine)
7.	Antiemetics
8.	ramosetron (Nasea)
9.	tropisetron (Navoban)
10.	5-HT3 Serotonin Receptors (5 HT3 Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Tonsillectomy
3.	Laparoscopic Cholecystectomy
4.	Gynecologic Surgical Procedures (Gynecologic Surgery)
5.	Adenoidectomy