Advanced glycation end products are associated with sarcopenia in older women: aging marker dynamics.

Abstract

The aim of this study was to determine whether advanced glycation end products (AGEs) revealed by skin autofluorescence (SAF), serum and urine pentosidine level, and serum homocysteine level can serve as a biomarker for sarcopenia in older women. The participants were 70 elderly women. The AGEs pentosidine, homocysteine, and SAF were measured as aging markers. This study shows that among the biomarkers for aging, serum pentosidine correlates with a loss of appendicular lean mass and can serve as a biomarker for sarcopenia. Moreover, SAF and homocysteine values exhibited a positive correlation with age and correlated with each other.Abbreviations: AGEs: advanced glycation end products; BIA: bioelectrical impedance analyzer; BMD: bone mineral density; DLS: degenerative lumbar scoliosis; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunoassay; HHcy: hyperhomocysteinemia; RIA: radioimmunoassay; SAF: skin autofluorescence; SMI: skeletal muscle mass index; T2DM: type 2 diabetes patients.

• Authors: Yawara Eguchi, Toru Toyoguchi, Kazuhide Inage, Kazuki Fujimoto, Sumihisa Orita, Miyako Suzuki, Hirohito Kanamoto, Koki Abe, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Yasuchika Aoki, Junichi Nakamura, Tsutomu Akazawa, Kazuhisa Takahashi, Seiji Ohtori
• Journal: Journal of women & aging (J Women Aging) 2021 May-Jun Vol. 33 Issue 3 Pg. 328-340 ISSN: 1540-7322 [Electronic] England
• PMID: 31770087 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Glycation End Products, Advanced

Topics

• Aged
• Aging (blood)
• Biomarkers (blood)
• Diabetes Mellitus, Type 2 (blood)
• Female
• Glycation End Products, Advanced (blood)
• Humans
• Quality of Life
• Sarcopenia (blood, complications, diagnosis)