Treatment of rectovaginal endometriosis with the etonogestrel-releasing contraceptive implant.

Abstract

This study aimed to investigate the efficacy of the etonogestrel (ENG)-releasing implant in treating patients with rectovaginal endometriosis. The study was based on the retrospective analysis of a prospectively collected database, including symptomatic women who had ultrasonographic diagnosis of rectovaginal endometriosis. Patients were follow-up at 6, 12 and 24 months from the insertion of the ENG-releasing implant. The intensity of pain symptoms was evaluated using a visual analog scale. The volume of the nodules was estimated by virtual organ computer-aided analysis. The Endometriosis Health Profile (EHP-30) was used to evaluate quality of life. Overall, 43 women were included in the study. The 2-year continuation rate for the ENG-releasing implant was 93.0%. The treatment quickly improved the intensity of non-menstrual pelvic pain, deep dyspareunia, dysmenorrhea, and dyschezia. At 6-month follow-up, there were improvements in all domains of the EHP-30 compared with baseline. Further improvements in the EHP-30 results were observed only in pain sub score at 12-month follow-up and in emotional well-being sub score at 24-month follow-up. At 6-month follow-up the volume of the rectovaginal nodules was significantly lower compared with baseline; a further decrease was observed at 12- and 24-month follow-up. The treatment was well tolerated.

• Authors: Simone Ferrero, Carolina Scala, Stefano Ciccarelli, Valerio Gaetano Vellone, Fabio Barra
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 36 Issue 6 Pg. 540-544 (Jun 2020) ISSN: 1473-0766 [Electronic] England
• PMID: 31711348 (Publication Type: Journal Article)

Chemical References

• Contraceptive Agents, Female
• Contraceptive Agents, Hormonal
• Drug Implants
• etonogestrel
• Desogestrel

Topics

• Adult
• Contraceptive Agents, Female (administration & dosage, adverse effects)
• Contraceptive Agents, Hormonal (administration & dosage, adverse effects)
• Desogestrel (administration & dosage, adverse effects)
• Drug Implants
• Dysmenorrhea (drug therapy)
• Dyspareunia (drug therapy)
• Endometriosis (drug therapy)
• Female
• Follow-Up Studies
• Humans
• Italy
• Pain Measurement
• Pelvic Pain (drug therapy)
• Quality of Life
• Rectal Diseases (drug therapy)
• Retrospective Studies
• Treatment Outcome
• Vaginal Diseases (drug therapy)