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3-keto-desogestrel (etonogestrel)

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metabolite of DESOGESTREL; structure given in first source; Implanon: implant containing etonogestrel (3-keto-desogestrel)

Also Known As:

etonogestrel; Implanon; 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one; 3-ketodesogestrel; 3-oxo desogestrel; 3-oxodesogestrel; Nourypharma brand of 3-keto-desogestrel; Organon brand of 3-keto-desogestrel; 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-

Networked: 111 relevant articles (8 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Norsteroids: 12
    - Norpregnanes: 1
      - Norpregnenes
        Desogestrel: 239
        3-keto-desogestrel: 111

Experts

1.	Fraser, Ian S: 5 articles (12/2011 - 06/2007)
2.	Bahamondes, Luis: 3 articles (09/2015 - 05/2006)
3.	Marnach, Mary L: 3 articles (05/2014 - 05/2011)
4.	Casey, Petra M: 3 articles (05/2014 - 05/2011)
5.	Long, Margaret E: 3 articles (05/2014 - 05/2011)
6.	Prous, J R: 3 articles (01/2006 - 01/2003)
7.	Rabasseda, X: 3 articles (01/2006 - 01/2003)
8.	Bayés, M: 3 articles (01/2006 - 01/2003)
9.	Teal, Stephanie: 2 articles (09/2015 - 01/2014)
10.	Cagnacci, Angelo: 2 articles (06/2015 - 12/2005)

Related Diseases

1.	Hemorrhage 08/01/2009 - "We compared four treatments against a placebo in Implanon users and tested whether repeated treatment improved subsequent bleeding patterns. " 09/01/2010 - "The study was conducted to evaluate the bleeding pattern, efficacy and discontinuation rate of etonogestrel implant (68 mg) inserted in postpartum adolescents. " 01/01/2006 - "The aim of this study was to compare three treatments with placebo on the duration and recurrence of frequent and/or prolonged bleeding in Implanon users. " 03/01/1999 - "In conclusion, this pilot efficacy study indicates that Implanon provides excellent contraceptive reliability and an acceptable bleeding pattern. " 03/01/1999 - "In this 4-year open-label, noncomparative, single-center pilot efficacy study, the contraceptive efficacy, safety, bleeding pattern and acceptability of Implanon was studied in 200 sexually active women of proven fertility in Indonesia. "
2.	Endometriosis (Adenomyosis) 10/01/2005 - "To evaluate the efficacy of Implanon on treatment of symptomatic endometriosis An open clinical study without control group Family Planning Clinic and out patient department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. " 01/01/2005 - "Our study was not planned research but a series of case studies of women with severe symptoms of endometriosis treated in an innovative way with a new long-acting progestogen contraceptive system (etonogestrel subdermal implant) which could reasonably have been expected to have a favourable effect on their disease and its symptoms. " 10/01/2005 - "Implanon, a sub-dermalprogestin implant is an effective hormonal alternative for treatment of symptomatic endometriosis. " 10/01/2005 - "The effects of implanon in the symptomatic treatment of endometriosis." 01/01/2005 - "Etonogestrel subdermal implants are an additional treatment option in women with symptoms related to pelvic endometriosis."
3.	Dysmenorrhea (Menstrual Pain) 01/01/2009 - "Implanon has been reported to be effective in the treatment of dysmenorrhea. " 09/15/2010 - "Implanon, the single-rod implantable contraceptive device, may reduce symptoms of dysmenorrhea. " 12/01/1998 - "Dysmenorrhea clearly improved during use of both Implanon and Norplant. " 12/01/2007 - "Implanon has been shown to be safe to use during lactation, may improve dysmenorrhea, and does not significantly affect bone mineral density, lipid profile, or liver enzymes." 03/01/2010 - "This prospective cohort evaluated clinical aspects (dysmenorrhea, headache, breast tenderness, leg pain and irritability), body weight and blood pressure changes in 75 women (18-37 years of age) using a vaginal ring releasing 120 mcg of etonogestrel and 15 mcg of ethinyl estradiol daily, over a continuous period of 84 days, followed by a 7-day ring-free interval, during 1 year. "
4.	Acne Vulgaris 12/01/1998 - "The adverse events that most often caused discontinuation of Implanon were weight gain and acne. " 12/01/1998 - "The development or aggravation of acne was a frequent adverse event (in 18.5% of Implanon and 22.3% of Norplant users in the comparative studies) but individual studies indicated that there were also many subjects whose acne improved during implant use. " 10/25/2003 - "Three women developed severe acne vulgaris within several weeks to a few months after either insertion of a levonorgestrel IUD (two women, 27 and 33 years of age) or subcutaneous implantation of an etonogestrel implant (26-year-old woman). "
5.	Pain (Aches) 09/01/2000 - "Implanon is easy to insert and remove with minimal complications and pain. " 07/01/2006 - "However, injury to branches of the medial antebrachial cutaneous nerve during Implanon insertion and removal can result in impaired sensibility, severe localized pain, or the formation of painful neuroma that can be quite devastating to the patient. " 01/01/2009 - "After 6 months, the average decrease in pain was 68% in the Implanon group and 53% in the DMPA group. " 01/01/2009 - "Concerning pain relief, the therapeutic efficacy of the contraceptive implant Implanon is not inferior to that of DMPA in symptomatic endometriosis." 01/01/2009 - "Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis--a pilot study."

Related Drugs and Biologics

1.	Levonorgestrel (Plan B)
2.	Mifepristone (RU 486)
3.	Doxycycline (Vibramycin)
4.	Ethinyl Estradiol (Estinyl)
5.	N,N-dimethyl-4-anisidine (DMPA)
6.	drospirenone
7.	Aldosterone
8.	3-keto-desogestrel (etonogestrel)
9.	Medroxyprogesterone Acetate (Depo-Provera)
10.	Desogestrel

Related Therapies and Procedures

1.	Female Contraceptive Devices (Vaginal Ring)
2.	Injections
3.	Contraception (Birth Control)
4.	Contraceptive Devices (Contraceptive Device)
5.	Copper Intrauterine Devices