Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases.

Abstract

The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.

• Authors: Subash C Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B Challagundla
• Journal: Biochimica et biophysica acta. Reviews on cancer (Biochim Biophys Acta Rev Cancer) Vol. 1873 Issue 1 Pg. 188316 (01 2020) ISSN: 1879-2561 [Electronic] Netherlands
• PMID: 31639408 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• MicroRNAs
• NF-kappa B
• RNA, Long Noncoding

Topics

• Animals
• Disease Models, Animal
• Gene Expression Regulation
• Genetic Predisposition to Disease (genetics)
• Humans
• MicroRNAs (genetics)
• NF-kappa B (genetics)
• Neoplasms (genetics, pathology)
• RNA, Long Noncoding (genetics)
• Signal Transduction (genetics)