Effects of different therapeutic modalities for postacne scars on circulating collagen III.

Abstract

BACKGROUND:

Therapies for postacne scarring act through modulation of elastin and collagen, and collagen III might therefore represent a biomarker of treatment effectiveness.

PATIENTS AND METHODS:

Patients (n = 70) with postacne scars and individuals without scars (n = 56) were included in this case-control study. Patients were treated with Dermaroller microneedling, trichloroacetic acid chemical reconstruction, punch excision, or scar subcision. Scar severity was graded immediately before and after treatment with a photographic quartile scale and the ECCA scale. Serum levels of collagen III were measured in control individuals and in patients, before treatment, 1 month after the first treatment session, and 4 months after the final session.

RESULTS:

Circulating levels of collagen III were significantly higher in patients with postacne scarring (24.1 ± 12.5) before treatment than in control individuals (2.6 ± 0.8). Circulating levels of collagen in patients were significantly lower 4 months posttreatment (14.3 ± 8.1) than at baseline. The mean percentage change in serum collagen III was positively correlated with both the mean percentage improvement by photographic evaluation (r = .530, P < .000) and the mean percentage change in the ECCA scale (r = .632, P < .000).

CONCLUSION:

Circulating collagen III is a biomarker for improvement of postacne scarring following different therapies.

• Authors: Ensaf M Abdel-Magiud, Emad A Taha, Radwa M Bakr, Sahar A Ismail, Sohair K Sayed, Mohamed Makboul, Suzan Kamel-ElSayed, Amira A Abdel Motaleb
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 19 Issue 6 Pg. 1517-1521 (Jun 2020) ISSN: 1473-2165 [Electronic] England
• PMID: 31638311 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Biomarkers
• Caustics
• Collagen Type III
• Trichloroacetic Acid

Topics

• Acne Vulgaris (complications, therapy)
• Adolescent
• Adult
• Biomarkers (blood)
• Case-Control Studies
• Caustics (administration & dosage)
• Cicatrix (blood, diagnosis, etiology, therapy)
• Collagen Type III (blood, metabolism)
• Dry Needling
• Female
• Humans
• Hypertrophy (diagnosis, etiology, therapy)
• Male
• Photography
• Severity of Illness Index
• Skin (diagnostic imaging, drug effects, metabolism, pathology)
• Treatment Outcome
• Trichloroacetic Acid (administration & dosage)
• Young Adult