A DNA-Azobenzene Nanopump Fueled by Upconversion Luminescence for Controllable Intracellular Drug Release.

Abstract

Stimulus-responsive drug release possesses considerable significance in cancer therapy. This work reports an upconversion-luminescence-fueled DNA-azobenzene nanopump for rapid and efficient drug release. The nanopump is constructed by assembling the azobenzene-functionalized DNA strands on upconversion nanoparticles (UCNPs). Doxorubicin (DOX) is loaded in the nanopump by intercalation in the DNA helix. Under NIR light, the UCNPs emit both UV and visible photons to fuel the continuous photoisomerization of azo, which acts as an impeller pump to trigger cyclic DNA hybridization and dehybridization for controllable DOX release. In a relatively short period, this system demonstrates 86.7 % DOX release. By assembling HIV-1 TAT peptide and hyaluronic acid on the system, targeting of the cancer-cell nucleus is achieved for perinuclear aggregation of DOX and enhanced anticancer therapy. This highly effective drug delivery nanopump could contribute to chemotherapy development.

• Authors: Yue Zhang, Yue Zhang, Guobin Song, Yuling He, Xiaobo Zhang, Ying Liu, Huangxian Ju
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 58 Issue 50 Pg. 18207-18211 (12 09 2019) ISSN: 1521-3773 [Electronic] Germany
• PMID: 31583799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antibiotics, Antineoplastic
• Azo Compounds
• tat Gene Products, Human Immunodeficiency Virus
• Doxorubicin
• Hyaluronic Acid
• DNA
• azobenzene

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics)
• Azo Compounds (chemistry)
• Crystallography, X-Ray
• DNA (chemistry)
• Doxorubicin (administration & dosage, pharmacokinetics)
• Drug Delivery Systems (methods)
• Drug Liberation
• Drug Stability
• Hep G2 Cells
• Humans
• Hyaluronic Acid (chemistry)
• Luminescence
• Male
• Mice, Inbred BALB C
• Nanoparticles (administration & dosage, chemistry)
• Ultraviolet Rays
• Xenograft Model Antitumor Assays
• tat Gene Products, Human Immunodeficiency Virus (chemistry)