Cardiovascular complications and its relationship with functional outcomes in Guillain-Barré syndrome.

Abstract

BACKGROUND:

Guillain-Barré syndrome (GBS) is a monophasic disease characterized by acute polyradiculoneuropathy.

AIM:

This study investigated cardiovascular complications in patients with GBS and their relationship with outcomes.

DESIGN AND METHODS:

We included 96 patients, who were diagnosed with GBS according to Brighton case definitions. All enrolled patients were evaluated according to a predetermined algorithm, which included nerve conduction studies, cerebrospinal fluid analysis, electrocardiography, 2D echo, cardiac markers and autonomic function testing.

RESULTS:

We enrolled a total of 96 patients. The mean age of patients was 35.75 ± 17.66 years. Furthermore, 54.2% of patients developed cardiovascular complications, of which changes in electrocardiography (ECG) findings (50%), hypertension (28.12%), labile hypertension (12.5), tachycardia (26.04), bradycardia (13.54%) and a fluctuating heart rate (HR) (11.46) were common. Other cardiovascular complications seen in GBS patients were increased pro-BNP (26.04%), raised troponin T levels (3.12%), acute coronary syndrome (2.08%), heart failure (2.08%) and abnormal 2D echo findings (8.33%). The results of the univariate analysis revealed that a history of preceding infection, a Medical Research Council sum score, neck muscle weakness, facial nerve involvement, bulbar involvement, respiratory failure, cardiovascular complications, autonomic dysfunction, acute motor sensory axonal neuropathy subtype and baseline Hughes score were significantly (P < 0.005) associated with poor outcomes. However, none of these factors were found to be independently associated with poor outcomes in the multivariate analysis.

CONCLUSION:

A considerable number of patients with GBS developed cardiovascular complications and it needs attention.

• Authors: S Gupta, R Verma, R Sethi, R K Garg, H S Malhotra, P K Sharma, I Rizvi, R Uniyal
• Journal: QJM : monthly journal of the Association of Physicians (QJM) Vol. 113 Issue 2 Pg. 93-99 (Feb 01 2020) ISSN: 1460-2393 [Electronic] England
• PMID: 31504947 (Publication Type: Journal Article, Observational Study)
• Copyright: © The Author(s) 2019. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: [email protected].

Topics

• Adolescent
• Adult
• Cardiovascular Diseases (diagnosis, etiology)
• Echocardiography
• Electrocardiography
• Female
• Guillain-Barre Syndrome (complications)
• Humans
• India
• Logistic Models
• Male
• Middle Aged
• Prospective Studies
• Young Adult