Abstract | BACKGROUND: METHODS: Volunteers with MetS (n = 42) were matched for age and gender and randomly assigned to a 12-wk weight loss program followed by 4-wk weight stabilization or a 16-wk weight maintenance program. At baseline and 16 weeks, isolated neutrophils were stimulated with calcium ionophore and the released SPM were measured by LC-MS/MS. RESULTS: At baseline the SPM resolvin (Rv) E1, 18R-RvE3, RvD2 and Maresin-1 (MaR-1) were detected from stimulated neutrophils. The concentration of released RvE1 was at least 6-fold that of other detected SPM. Weight loss of 4.7 ± 0.8 kg, led to a 2-fold increase in RvE1, P = 0.013, relative to the weight maintenance group. The increase in RvE1 after weight loss was related to, but independent of leukotriene B4. CONCLUSION: Following weight loss, human neutrophils from individuals with the metabolic syndrome are capable of releasing larger amounts of RvE1 upon stimulation.
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Authors | A Barden, S Shinde, I-J Tsai, K D Croft, L J Beilin, I B Puddey, T A Mori |
Journal | Prostaglandins, leukotrienes, and essential fatty acids
(Prostaglandins Leukot Essent Fatty Acids)
Vol. 148
Pg. 25-29
(09 2019)
ISSN: 1532-2823 [Electronic] Scotland |
PMID | 31492430
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Ltd. All rights reserved. |
Chemical References |
- 17,18-dihydroxyeicosapentaenoic acid
- 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
- Calcium Ionophores
- Fatty Acids, Unsaturated
- resolvin D2
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
- 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid
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Topics |
- Adult
- Aged
- Calcium Ionophores
(pharmacology)
- Chromatography, Liquid
- Docosahexaenoic Acids
(analysis)
- Eicosapentaenoic Acid
(analogs & derivatives, analysis)
- Fatty Acids, Unsaturated
(analysis)
- Female
- Humans
- Male
- Metabolic Syndrome
(metabolism, therapy)
- Middle Aged
- Neutrophils
(drug effects, metabolism)
- Tandem Mass Spectrometry
- Weight Reduction Programs
(methods)
- Young Adult
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