Abstract | BACKGROUND AND AIMS: METHODS: This study included 412 patients with superficial colorectal neoplasms that were resected by ESD between June 2010 and June 2018. The patients were classified into two groups: without antithrombotics (n = 286) and with anticoagulants (n = 51). The anticoagulants group was further divided into two groups: warfarin (n = 26) and DOAC (n = 25). RESULTS: Among all patients, delayed bleeding occurred in 35 (8.5% [35/412]) patients. The bleeding rate in the anticoagulants group (11.8% [6/51]) was higher than that in the group without antithrombotics (6.6% [19/286]), but the difference was not statistically significant (P = 0.240). The bleeding rate in the DOAC group (16.0% [4/25]) was higher than that in the warfarin group (7.7% [2/26]), but the difference was not statistically significant (P = 0.419). All delayed bleeding was successfully managed with endoscopic hemostasis. Thromboembolic events were not observed in any patients. CONCLUSIONS:
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Authors | Hideaki Harada, Ryotaro Nakahara, Daisuke Murakami, Satoshi Suehiro, Takuya Nagasaka, Tetsuro Ujihara, Ryota Sagami, Yasushi Katsuyama, Kenji Hayasaka, Shigetaka Tounou, Yuji Amano |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 34
Issue 8
Pg. 3330-3337
(08 2020)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 31482349
(Publication Type: Journal Article)
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Chemical References |
- Anticoagulants
- Factor Xa Inhibitors
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Topics |
- Anticoagulants
(administration & dosage, adverse effects, therapeutic use)
- Colon
(surgery)
- Colorectal Neoplasms
(surgery)
- Endoscopic Mucosal Resection
- Factor Xa Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Postoperative Hemorrhage
(epidemiology)
- Rectum
(surgery)
- Risk Factors
- Thromboembolism
(drug therapy, prevention & control)
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