Predictors for Fibrosis Regression in Chronic HCV Patients after the Treatment with DAAS: Results of a Real-world Cohort Study.

Abstract

INTRODUCTION:

The goal of treatment of chronic hepatitis C (HCV) is viral eradication. However, obtaining histological regression is even more important, because it will reduce the overall morbidity and mortality related to cirrhosis. Introduction of direct-acting antivirals (DAAs) in HCV improves rates of sustained virologic response (SVR). However, fibrosis regression has not been extensively assessed. The aim of this study was to detect the factors affecting fibrosis regression in chronic HCV patients treated with interferon containing regimens versus interferon-free DAA regimens.

METHODS:

This prospective observational cohort study was conducted at the Tropical Medicine and Infectious Diseases Department, Tanta University, Egypt, between October 2015 and December 2017. Transient elastography (FibroScan®) examination was performed before therapy, at SVR12, 6 months and 1 year after completing therapy for cured patients.

RESULTS:

Reduction in fibrosis was reported in; 46.7% and 49.3% of patients with moderate fibrosis, and 89% and 78.7% of patients with advanced fibrosis after one year of interferon containing and interferon free DAAs regimens respectively. Using multiple regression analysis; it was found that BMI, degrees of hepatic stiffness and steatosis were related to regression of hepatic fibrosis after therapy.

CONCLUSION:

DAAs with or without interferon resulted in a significant reduction of liver fibrosis. BMI, steatosis and liver stiffness were independent factors for fibrosis regression in chronic HCV patients treated with DAAs. Further studies are needed to explore the mechanism by which steatosis affects HCV related fibrosis regression after treatment with DAAs.

• Authors: Hanan Soliman, Dina Ziada, Marwa Salama, Manal Hamisa, Rehab Badawi, Nehad Hawash, Amal Selim, Sherief Abd-Elsalam
• Journal: Endocrine, metabolic & immune disorders drug targets (Endocr Metab Immune Disord Drug Targets) Vol. 20 Issue 1 Pg. 104-111 ( 2020) ISSN: 2212-3873 [Electronic] United Arab Emirates
• PMID: 31448717 (Publication Type: Comparative Study, Journal Article, Observational Study)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Antiviral Agents
• Interferons

Topics

• Adult
• Antiviral Agents (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Egypt
• Elasticity Imaging Techniques
• Female
• Hepatitis C, Chronic (diagnosis, drug therapy, virology)
• Humans
• Interferons (adverse effects, therapeutic use)
• Liver (diagnostic imaging, drug effects, virology)
• Liver Cirrhosis (diagnostic imaging, drug therapy, virology)
• Male
• Middle Aged
• Prospective Studies
• Remission Induction
• Sustained Virologic Response
• Time Factors
• Treatment Outcome