Anti-TSNARE1 IgG plasma levels differ by sex in patients with schizophrenia in a Chinese population.

Abstract

It was recently reported that levels of plasma IgG antibodies against peptide antigens derived from proteins encoded by schizophrenia-associated genes are altered in individuals with schizophrenia treated with antipsychotics. This study aimed to replicate the initial finding in antipsychotic-naïve patients with first-episode schizophrenia and to explore the possible mechanism by which immune tolerance of B cells may be altered in this disease. A total of 408 case-control plasma samples were collected for analysis of circulating IgG antibodies against fragments derived from TCF4, TSNARE1, ZNF804A, TRANK1, ERCC4, DPYD and CD25 using an in-house ELISA. The Mann-Whitney U-test revealed that patients with schizophrenia had a significant change in plasma anti-TSNARE1 and anti-CD25 IgG levels; male patients mainly contributed to the increased levels of anti-TSNARE1 IgG and anti-CD25 IgG. Receiver operating characteristic (ROC) curve analysis revealed that the anti-TSNARE1 IgG assay had an area under the ROC curve of 0.625 with a sensitivity of 15.7% and a specificity of 95.2%. Work on a B-cell model revealed that TRANK1-derived antigen treatments could enhance the proportions of CD83+ cells and apoptotic B cells when compared with TSNARE1-derived antigen and vehicle treatment. We conclude that there is a gender difference in autoimmune responses in schizophrenia and suggest that anti-TSNARE1 IgG may be indicative of schizophrenia in a subgroup of male patients.

• Authors: Chan Li, Ruth Whelan, Hua Yang, Yaling Jiang, Chaosen Qiu, Qingyong Meng, Jun Wei
• Journal: FEBS open bio (FEBS Open Bio) Vol. 9 Issue 10 Pg. 1705-1712 (10 2019) ISSN: 2211-5463 [Electronic] England
• PMID: 31336035 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

Chemical References

• Immunoglobulin G
• SNARE Proteins
• TSNARE1 protein, human

Topics

• Adult
• Asian People
• China
• Female
• Humans
• Immunoglobulin G (blood, immunology)
• Male
• SNARE Proteins (immunology)
• Schizophrenia (blood)
• Sex Characteristics