This review examines some of the reasons why we don't have a
vaccine against
autoimmune diseases and highlights the progress that has been made. Many
autoimmune diseases, such as
rheumatoid arthritis (RA),
multiple sclerosis (MS) and
type 1 diabetes (T1D), are driven by autoimmune T cell responses. Unlike
vaccines for most
infectious diseases, which elicit antibody responses, are intended for immuno-naive individuals and considered preventative, a
vaccine for an
autoimmune disease must be therapeutic and resolve or control the on-going autoimmune response and condition in the diseased host. Despite these differences, many of the same considerations for
infectious disease vaccines must also be addressed to develop a therapeutic
vaccine for
autoimmune diseases. The disease initiator/triggers,
antigens and
autoantigens, nature of the immunopathogenic and protective/therapeutic immune response will be compared for infectious and
autoimmune diseases as will approaches for developing
vaccines including formulations, animal models and indicators of success. The rationale for a therapeutic
vaccine for RA will be discussed in greater detail with a relatively limited discussion of T1D, MS and other
autoimmune diseases.