High EGFL7 expression may predict poor prognosis in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.

Abstract

Epithelial growth factor-like 7 (EGFL7) is a secretory protein with a well-characterized role in angiogenesis and the oncogenesis of certain solid tumors. Overexpression of EGFL7 is associated with adverse prognosis in patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, whether this association persists after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. To further clarify the prognostic role of EGFL7, seventy-one AML patients with EGFL7 expression data who underwent allo-HSCT from The Cancer Genome Atlas database were included and divided into either EGFL7high or EGFL7low group based on the median EGFL7 expression level. Two groups had similar clinical and molecular characteristics except that the EGFL7high group had less frequent NPM1 mutations (P= .001). Kaplan-Meier survival curves showed that high EGFL7 expressers had shorter OS than the low expressers (P= .040). Univariate analysis showed that high EGFL7 expression, MLL-PTD, RUNX1 and TP53 mutations were associated with short OS (all P< .05). Multivariate analysis indicated that high EGFL7 expression, FLT3-ITD, RUNX1 and TP53 mutations were independent risk factors for OS (all P< .05). Collectively, our study suggested that EGFL7, like the other widely-used risk stratification factors, could serve as a prognostic tool and therapeutic target in AML, even after allo-HCST.

• Authors: Zhiheng Cheng, Yifeng Dai, Yifan Pang, Yang Jiao, Yan Liu, Longzhen Cui, Tingting Qian, Liang Quan, Wei Cui, Yue Pan, Xu Ye, Jinlong Shi, Lin Fu
• Journal: Cancer biology & therapy (Cancer Biol Ther) Vol. 20 Issue 10 Pg. 1314-1318 ( 2019) ISSN: 1555-8576 [Electronic] United States
• PMID: 31306053 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Calcium-Binding Proteins
• EGF Family of Proteins
• EGFL7 protein, human
• NPM1 protein, human
• Nucleophosmin

Topics

• Adult
• Aged
• Biomarkers, Tumor
• Calcium-Binding Proteins (genetics, metabolism)
• Chromosome Aberrations
• Databases, Nucleic Acid
• EGF Family of Proteins (genetics, metabolism)
• Female
• Gene Expression
• Hematopoietic Stem Cell Transplantation (adverse effects, methods)
• Humans
• Kaplan-Meier Estimate
• Leukemia, Myeloid, Acute (diagnosis, genetics, mortality, therapy)
• Male
• Middle Aged
• Nucleophosmin
• Odds Ratio
• Prognosis
• Transplantation, Homologous