Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke.
Abstract | INTRODUCTION: Although pathogenesis of small vessel disease is poorly understood, increasing evidence suggests that endothelial dysfunction may have a relevant role in development and progression of small vessel disease. In this cross-sectional study, we investigated the associations between imaging signs of small vessel disease and blood biomarkers of endothelial dysfunction at two different time points in a population of ischaemic stroke patients. PATIENTS AND METHODS: RESULTS: DISCUSSION:
Leukoaraiosis and lacunes were associated with endothelial dysfunction, which could play a key role in pathogenesis of small vessel disease. CONCLUSIONS: Small vessel disease features and total burden were associated with endothelial dysfunction 90 days after the stroke, whereas there was no relation during the acute phase. Our results suggest that endothelial dysfunction, particularly vascular endothelial growth factor, is involved in pathological process of small vessel disease.
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Authors | Francesco Arba, Alessio Giannini, Benedetta Piccardi, Silvia Biagini, Vanessa Palumbo, Betti Giusti, Patrizia Nencini, Anna Maria Gori, Mascia Nesi, Giovanni Pracucci, Giorgio Bono, Paolo Bovi, Enrico Fainardi, Domenico Consoli, Antonia Nucera, Francesca Massaro, Giovanni Orlandi, Francesco Perini, Rossana Tassi, Maria Sessa, Danilo Toni, Rosanna Abbate, Domenico Inzitari |
Journal | European stroke journal
(Eur Stroke J)
Vol. 4
Issue 2
Pg. 119-126
(Jun 2019)
ISSN: 2396-9881 [Electronic] England |
PMID | 31259260
(Publication Type: Journal Article)
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