Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: A total of 400 patients underwent clomiphene citrate treatment for a mean ± SD of 25.5 ± 20.48 months (range 0 to 84). Of the patients 280 received clomiphene citrate for 3 years or less (mean 12.75 ± 9.52 months) and 120 received it for more than 3 years (mean 51.93 ± 10.52 months). Of men on clomiphene citrate for more than 3 years 88% achieved eugonadism, 77% reported improved symptoms and 8% reported side effects. Estradiol was significantly increased following clomiphene citrate treatment. Results did not significantly differ between patients treated for more than 3, or 3 or fewer years. The most common side effects reported by patients treated more than 3 years included changes in mood in 5, blurred vision in 3 and breast tenderness in 2. There was no significant adverse event in any patient treated with clomiphene citrate. CONCLUSIONS:
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Authors | Sarah C Krzastek, Devang Sharma, Natasha Abdullah, Mark Sultan, G Luke Machen, Jessica L Wenzel, Alex Ells, Xizhao Chen, Mehraban Kavoussi, Raymond A Costabile, Ryan P Smith, Parviz K Kavoussi |
Journal | The Journal of urology
(J Urol)
Vol. 202
Issue 5
Pg. 1029-1035
(11 2019)
ISSN: 1527-3792 [Electronic] United States |
PMID | 31216250
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Biomarkers
- Gonadotropins
- Selective Estrogen Receptor Modulators
- Clomiphene
- Testosterone
- Estradiol
- Prolactin
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Topics |
- Adult
- Biomarkers
(blood)
- Clomiphene
(administration & dosage)
- Dose-Response Relationship, Drug
- Estradiol
(blood)
- Follow-Up Studies
- Gonadotropins
(blood)
- Humans
- Hypogonadism
(blood, drug therapy)
- Male
- Prolactin
(blood)
- Retrospective Studies
- Selective Estrogen Receptor Modulators
(administration & dosage)
- Testosterone
(blood)
- Time Factors
- Treatment Outcome
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