Abstract | BACKGROUND: METHODS: A single-centre cross-sectional study was performed in 268 children and adolescents (116 males; mean age 13.03 ± 1.9 years,) with overweight/ obesity, in order to identify risk factors for early retinopathy. RESULTS: Nine patients (3.3%) showed signs of retinopathy, defined as arteriovenous crossings and/or papilledema. Body mass index and fat mass, analysed by Dual X-ray Absorptiometry, were not different in patients with or without retinopathy. Patients with retinopathy were pubertal and showed higher waist circumference (107.78 ± 15.83 versus 99.46 ± 10.85 cm; p: 0.027), waist circumference/height ratio (0.66 ± 0.07 versus 0.62 ± 0.05; p: 0.04) and IGF-I SDS (0.03 ± 1.3 versus - 0.66 ± 0.9; p: 0.04). Multivariate analysis (after correction for sex, age, family history of type 2 diabetes mellitus, obesity, cardiovascular disease, hypertension and dyslipidaemia) showed that waist circumference/height ratio and IGF-I SDS were the only variables independently correlated with the presence of retinopathy. CONCLUSIONS:
Retinal vascular changes may become evident as an early complication of overweight and obesity, even during childhood and adolescence. Relatively high levels of IGF-I during this phase may act as an additional risk factor for microvascular damage. The screening for retinopathy should be proposed to all children and adolescents with overweight/ obesity.
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Authors | Carla Bizzarri, Stefania Pedicelli, Antonino Romanzo, Sarah Bocchini, Giorgia Bottaro, Stefano Cianfarani, Marco Cappa |
Journal | Italian journal of pediatrics
(Ital J Pediatr)
Vol. 45
Issue 1
Pg. 52
(Apr 27 2019)
ISSN: 1824-7288 [Electronic] England |
PMID | 31029141
(Publication Type: Journal Article)
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Chemical References |
- IGF1 protein, human
- Insulin-Like Growth Factor I
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Topics |
- Adolescent
- Blood Pressure
- Body Mass Index
- Child
- Cohort Studies
- Cross-Sectional Studies
- Female
- Humans
- Insulin-Like Growth Factor I
(metabolism)
- Male
- Pediatric Obesity
(blood, complications)
- Puberty
(blood)
- Retinal Diseases
(blood, etiology)
- Risk Factors
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