Over the past decades,
periodontitis has become a rising health problem and caused various diseases. In the many studies shows that some extracts and compound to the prevention and treatment of
periodontitis. This study focuses on the effects of inhibition of gingival damage and
alveolar bone loss. The aim of this study was to evaluate the protective effects of Magnolia biondii extract (MBE) against
ligature-induced
periodontitis in rats. A
ligature was placed around the molar teeth for 8 weeks, and MBE was administered for 8 weeks. Gingival tissue damage and
alveolar bone loss were measured by microcomputed tomography (CT) analysis and histopathological examination. Serum Interluekin-1 β (IL-1β),
tumor necrosis factor-α (TNF-α), cyclooxygenases-2 (COX-2), and receptor activator of nuclear factor-κB
ligand (RANKL) levels were investigated using commercial kits to confirm the antiperiodontitis effects of MBE. We confirmed that
ligature-induced
periodontitis resulted in gingival tissue damage and
alveolar bone loss. However, treatment for 8 weeks with MBE protected from periodontal tissue damage and downregulated serum inflammatory
cytokine factors and RANKL levels. These results suggest that MBE exerts antiperiodontitis effects by inhibiting gingival tissue destruction and
alveolar bone loss through regulation of anti-inflammatory
cytokines in
periodontitis-induced rats.