Action of Reverse T3 on Cancer Cells.

Abstract

Background: Reverse T3 (rT3; 3,3',5'-triiodo-L-thyronine) is widely regarded as an inactive naturally occurring analog of thyroid hormone. rT3 is known to bind to the thyroid hormone analog receptor on plasma membrane integrin αvβ3. This integrin is generously expressed by tumor cells and is the initiation site for the stimulation by L-thyroxine (T4) at physiological free concentrations on cancer cell proliferation. Results: In the present studies, we show that rT3 caused increases of proliferation in vitro of 50% to 80% (P < 0.05-0.001) of human breast cancer and glioblastoma cells. Conclusion: rT3 may be a host factor supporting cancer growth.

• Authors: Hung-Yun Lin, Heng-Yuan Tang, Matthew Leinung, Shaker A Mousa, Aleck Hercbergs, Paul J Davis
• Journal: Endocrine research (Endocr Res) Vol. 44 Issue 4 Pg. 148-152 (Nov 2019) ISSN: 1532-4206 [Electronic] England
• PMID: 30943372 (Publication Type: Journal Article)

Chemical References

• Triiodothyronine, Reverse

Topics

• Adenocarcinoma (pathology)
• Brain Neoplasms (pathology)
• Breast Neoplasms (pathology)
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Female
• Glioblastoma (pathology)
• Humans
• MCF-7 Cells
• Neoplasms (pathology)
• Triiodothyronine, Reverse (pharmacology)
• Tumor Cells, Cultured