Thyronines

A group of metabolites derived from THYROXINE and TRIIODOTHYRONINE via the peripheral enzymatic removal of iodines from the thyroxine nucleus. Thyronine is the thyroxine nucleus devoid of its four iodine atoms.

Also Known As:

Networked: 89 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Yue-Feng: 3 articles (01/2017 - 01/2008)
2.	Gerdes, A Martin: 3 articles (01/2017 - 01/2008)
3.	Köhrle, Josef: 2 articles (12/2019 - 01/2017)
4.	Cioffi, Federica: 2 articles (01/2019 - 10/2010)
5.	Goglia, Fernando: 2 articles (01/2019 - 10/2010)
6.	Lanni, Antonia: 2 articles (01/2019 - 10/2010)
7.	Rajagopalan, Viswanathan: 2 articles (01/2017 - 01/2016)
8.	Zhang, Youhua: 2 articles (01/2017 - 01/2016)
9.	Bulzico, Daniel A: 2 articles (11/2014 - 06/2011)
10.	Meirelles, Ricardo M R: 2 articles (11/2014 - 06/2011)

Related Diseases

1.	Low Cardiac Output 07/01/2000 - "Whether routine administration of intravenous tri-iodo thyronine is beneficial in the prevention of low cardiac output syndrome seen after CPB remains to be elucidated in future."
2.	Hyperthyroidism 05/01/1985 - "The hyperthyroid state of the animals was ascertained by measurements of plasma levels of tri-iodo-thyronine and T4. " 04/01/1967 - "[Prognostic significance of thyroid function tests in hyperthyroid patients after 131-I treatment--with special reference to the L-triiodo-thyronine inhibition test]." 08/01/2006 - "This study aimed to investigate this possibility by means of the induction of a neonatal hyperthyroidism in rats (4 mug of 3,5,3'-triiodo-l-thyronine (T3)/100 g body weight, s.c.) for 5, 15 or 30 days, and further evaluation of GH gene expression, as well as its physiological consequences in adult rats subjected to a transient hyperthyroidism in the first 30 days of life. " 09/25/1989 - "N-bromoacetyl-3,3',5-tri[3'-125I]iodo-L-thyronine was used to label intact heart mitochondria from eu, hypo- and hyperthyroid rats in order to identify proteins involved in T3-regulated mitochondrial processes. " 08/01/1987 - "We have compared the vasopressor response of alpha-adrenoceptor agonists in young (2 month-old) and older (12 month-old) pithed rats both in the presence and absence of triiodo-L-thyronine (T3)-induced hyperthyroidism. "
3.	Hypothyroidism 04/01/1984 - "Mass spectral properties of volatile derivatives of thyronine (T0) and use of these in the study of thyronine excretion in eu-, hyper- and hypothyroidism." 03/01/1961 - "[Treatment of hypothyroidism with D-thyronine. " 01/01/2022 - "On day 10 after TThy, hypothyroidism was confirmed via thyronine (T3 and T4) and thyroid-stimulating hormone serum levels. " 01/01/2001 - "In this study, we demonstrated that 6-n-propyl-2-thiouracil (PTU)-induced hypothyroidism stimulated, whereas triido-L-thyronine (T(3))-induced hyperthyroidism suppressed, PC1 mRNA levels in the rat anterior pituitary. " 12/01/1987 - "L-thyroxine and triiodo-L-thyronine concentrations in cerebrospinal fluid (CSF), hypothalamus and pituitary gland are measured in male albino-Wistar rats under several experimental thyroid disfunction : including hyperthyroidism induced by L-T3 and L-T4 treatments and surgical hypothyroidism. "
4.	Body Weight (Weight, Body) 04/26/2002 - "Male adult guinea pigs were intramuscularly injected with 2 mg/kg body weight of thyronine. " 01/01/1992 - "A positive and significant correlation (p < 0.005) between body weight and T3 was observed, confirming the active participation of this thyronine in growth processes." 01/01/1987 - "50, 100 or 150 micrograms/100 g body weight/day of very pure 3,3',5' triiodo-L-thyronine (rT3), obtained from a new synthetic method, was intraperitoneally administered in male Wistar rats for 5 weeks. " 08/01/2006 - "This study aimed to investigate this possibility by means of the induction of a neonatal hyperthyroidism in rats (4 mug of 3,5,3'-triiodo-l-thyronine (T3)/100 g body weight, s.c.) for 5, 15 or 30 days, and further evaluation of GH gene expression, as well as its physiological consequences in adult rats subjected to a transient hyperthyroidism in the first 30 days of life. " 12/01/1981 - "The development of a fast-growing hepatoma (HW-165) in normal euthyroid Wistar rats, was shown to be stimulated by daily injection of a dose of triiodo-L-thyronine (T3) as low as 1.5 microgram/100 g body weight. "
5.	Cardiomegaly (Heart Hypertrophy) 08/01/2004 - "Chronic treatment of rats with 3,5,3' triiodo-L-thyronine (T3) resulted in a prominent increase in the size of the left ventricle with increased wall thickness and reduced chamber volume leading to concentric cardiac hypertrophy. " 03/01/1991 - "Administration of triiodo-L-thyronine (0.25 mg/kg), a level known to promote cardiac hypertrophy, did not produce elevated levels of c-fos or c-myc mRNA. " 03/01/1977 - "1. Studies on three models of cardiac hypertrophy (aortic constriction, application of isoproterenol, daily administrations of 3,3'5-triiodo-L-thyronine, respectively) reveal that the enhancement of de novo synthesis of adenine nucleotides occurs very early during the development of cardiac hypertorphy and always precedes the increase of protein synthesis. "

Related Drugs and Biologics

1.	Thyroid Hormones
2.	Thyroxine (Levothyroxine)
3.	Proteins (Proteins, Gene)
4.	Iodine
5.	Messenger RNA (mRNA)
6.	Calcium
7.	Adenine Nucleotides
8.	Phosphates (Orthophosphate)
9.	Isoproterenol (Isoprenaline)
10.	Hydroxyproline (4 Hydroxyproline)

Related Therapies and Procedures

1.	Mass Drug Administration
2.	Therapeutics
3.	Injections
4.	Ligation