IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes.

Abstract

An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Postoperatively, his uni-nephrectomy necessitated hemodialysis, but the patient's insulin resistance was ameliorated; no medication was required to control diabetes, suggesting that the tumor had caused the insulin resistance. This report describes a case of a tumor secreting interleukin-6, which affects both the control of diabetes and CKD progression.

• Authors: Akira Okada, Takaaki Higashihara, Taiko Kusano, Koji Takemura, Hanako Saigusa, Sayako Maruno, Mimiko Matsumura, Takeo Suzuki, Akira Shimizu, Hideki Takano
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 58 Issue 13 Pg. 1953-1960 (Jul 01 2019) ISSN: 1349-7235 [Electronic] Japan
• PMID: 30918174 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interleukin-6
• Hexosaminidases

Topics

• Aged, 80 and over
• Carcinoma, Renal Cell (metabolism, pathology, surgery)
• Disease Progression
• Hexosaminidases (urine)
• Humans
• Interleukin-6 (metabolism)
• Kidney Neoplasms (surgery, urine)
• Male
• Nephrectomy (methods)
• Paraneoplastic Endocrine Syndromes (diagnosis, surgery)
• Renal Insufficiency, Chronic (diagnosis, surgery)
• Treatment Outcome