Impact of chrysin on the molecular mechanisms underlying diabetic complications.

Abstract

Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are common complications of diabetes that threats the patient's life. Chrysin (CH), a natural flavonoid, has several pharmacological effects, including antioxidant, antiapoptotic, anti-inflammatory, and anticancer. Strong scientific documents indicated that chrysin may be effective for preventing and treating complications of diabetes in experimental models. The present study was designed to review the association between chrysin administration and diabetes complications by focusing on the possible molecular pathway. The findings indicate that chrysin has protective effects against diabetes outcomes by modulating oxidative stress, inflammation, and apoptosis in animal models. However, more clinical trial study should be done to clear the protective effects of chrysin in diabetic patients.

• Authors: Tahereh Farkhondeh, Saeed Samarghandian, Babak Roshanravan
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 10 Pg. 17144-17158 (08 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30916403 (Publication Type: Journal Article, Review)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• Flavonoids
• chrysin

Topics

• Animals
• Diabetes Complications
• Diabetes Mellitus, Experimental (drug therapy)
• Flavonoids (pharmacology)
• Humans