Abstract |
Basal and pentagastrin stimulated gastric secretion was measured in seven patients with duodenal, and six with gastric ulcers before and after four weeks' treatment with colloidal bismuth subcitrate (as De-Nol), one tablet four times a day. Each duodenal and all but one of the gastric ulcers healed. After De-Nol there were no significant changes in basal, or pentagastrin stimulated volume, acid output, or primary parietal component. There were marked decreases in basal ( duodenal ulcer -25%; gastric ulcer -16%) and pentagastrin stimulated total pepsin outputs, ( duodenal ulcer -42%, gastric ulcer -36%). There were insignificant decreases in basal output of mucus, but postpentagastrin stimulated mucus output was significantly inhibited (p less than 0.05) in patients with duodenal (-16%) and with gastric ulcer (-27%). The drop in gastric proteolysis after De-Nol is unlikely to be because of the healing of the ulcers and is more likely to be because of the drug. The ulcer healing efficacy of De-Nol may be related to this decline in the proteolytic action of gastric juice, but is unlikely to be because of a quantitative change in mucus, or in acid secretion.
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Authors | J H Baron, J Barr, J Batten, R Sidebotham, J Spencer |
Journal | Gut
(Gut)
Vol. 27
Issue 5
Pg. 486-90
(May 1986)
ISSN: 0017-5749 [Print] England |
PMID | 3084345
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organometallic Compounds
- Pepsin A
- bismuth tripotassium dicitrate
- Bismuth
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Topics |
- Adult
- Aged
- Bismuth
(therapeutic use)
- Duodenal Ulcer
(drug therapy, metabolism)
- Female
- Gastric Acid
(metabolism)
- Gastric Mucosa
(drug effects, metabolism)
- Humans
- Male
- Middle Aged
- Mucus
(metabolism)
- Organometallic Compounds
- Pepsin A
(metabolism)
- Stomach Ulcer
(drug therapy, metabolism)
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