In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control.

Abstract

Tissue sealants are used for hemorrhage control which is imperative in many surgical procedures. It is a highly challenging task to obtain the ideal tissue sealant. Only a few commercially tissue sealants are available to be used for internal tissue or organ hemorrhage control. This study introduced two in situ injectable hydrogels for hemorrhage control: self-crosslinking gelatin (sc-G) hydrogel and hyaluronic acid/gelatin (HA/G) hydrogel. They were prepared on the tissue surface in situ and characterized by rheological analysis, stability, cytotoxicity, and bursting strength test. The hemostatic ability of the hydrogels was evaluated in a liver-bleeding rat model. The sc-G and HA/G hydrogels gelled around 90 s and 50 s, respectively. They were preferable for cell attachment and proliferation. The bursting strengths of both hydrogels exceeded that of fibrin glue. The hemostatic ability of HA/G hydrogel was better than that of sc-G hydrogel, and was same as that of fibrin glue. The HA/G hydrogel could be used as a tissue sealant for hemorrhage control in clinic.

• Authors: Jing-Wan Luo, Chang Liu, Jing-Heng Wu, Long-Xiang Lin, Hai-Ming Fan, Dan-Hui Zhao, Yong-Qing Zhuang, Yu-Long Sun
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 98 Pg. 628-634 (May 2019) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 30813066 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Biocompatible Materials
• Hydrogels
• Gelatin
• Hyaluronic Acid

Topics

• Animals
• Biocompatible Materials (chemistry)
• Gelatin (chemistry)
• Hemostasis
• Hyaluronic Acid (chemistry)
• Hydrogels (chemistry)
• Male
• Rats
• Rats, Sprague-Dawley
• Tissue Engineering (methods)
• Tissue Scaffolds (chemistry)