Abstract | BACKGROUND: METHODS: Sixteen male Wistar rats with an initial body weight of 220 ± 10 g were divided into the following two groups: (1) control and (2) ethanol (4.5 g/kg BW). RESULTS: After 6 weeks of treatment, the results revealed a significant increase in isoforms VEGFR1 and VEGFR2 of VEGFR gene expression, significant increases of MMP2 and MMP9 activities, as well as significant decrease of nephrin and podocin gene expressions in the ethanol group, compared with that in the control group. CONCLUSION: These findings indicate that ethanol-induced kidney abnormalities may be in part associated with alteration in expressions of VEGFRs, nephrin, and podocin and in increasing activities of MMP2 and MMP9 as key molecular mediators in the kidney function.
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Authors | Mahrokh Samadi, Alireza Shirpoor, Ali Taghizadeh Afshari, Fatemeh Kheradmand, Yousef Rasmi, Maryam Sadeghzadeh |
Journal | Interventional medicine & applied science
(Interv Med Appl Sci)
Vol. 10
Issue 3
Pg. 171-177
(Sep 2018)
ISSN: 2061-1617 [Print] Hungary |
PMID | 30713757
(Publication Type: Journal Article)
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